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Filtering by: Creator Han, Myung Woo Advisor Gould, Steven J.

Metabolism of L-α-arginine in the biosynthesis of blasticidin S

Creator:

Woo, Nam-tae

Abstract:

Two labelled arginines, DL-[2,3,3,-²H₃]arginine, 8, and DL-[ ¹³C, 2-¹⁵N]arginine, 9, were synthesized. These were fed to cultures of Streptomyces griseochromogenes in order to probe the mechanism of the apparent arginine-2,3- aminomutase reaction occurring in biosynthesis of blasticidin S, 1. In previous studies of the enzymes lysine-2,3- aminomutase and tyrosine-2,3-aminomutase different...

Resource Type:

Masters Thesis

Full Text:

blasticidin S AN ABSTRACT OF THE THESIS OF Nam-Tae Woo for the degree of Master of Science in Chemistry
Biosyntheis of Blasticidin S : pathway and enzymes for the nucleoside formation and blastidic acid assembly

Creator:

Guo, Jincan

Resource Type:

Dissertation

Full Text:

, 1981, 655, 335-341. 6. Woo, N-T. M.S Thesis, Oregon State University. 1985. 7. Shomura, T.; Inoue, M
Biosynthesis of blasticidin S : mechanistic and stereochemical investigations

Creator:

Prabhakaran, P. C.

Abstract:

Feeding of [3-¹³C, 2-¹⁵N]arginine, 38a, unequivocally established that the β- arginine moiety of blasticidin S, 1, was formed from α-arginine by an intramolecular migration of the α-amino group to the β- position. Further feedings using chirally deuteriated arginines 38e and 38f revealed that the aminomutase process occurred with inversion of...

Resource Type:

Dissertation