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Filtering by: Creator Hipkins, Valerie D. Advisor Ho, Emily Resource Type Dissertation

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:

Myzak, Melinda C.

Abstract:

Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...

Resource Type:

Dissertation

Full Text:

- Fageeh, Philip Tong, Chris Larsen, Robert Weston, Roland Corden, Maryam Mousaoui, Gayle Orner, Valerie
The function of zinc in the maintenance of DNA integrity in vivo

Creator:

Song, Yang

Abstract:

Approximately 12% of Americans do not consume the amount of zinc equal to the Estimated Average Requirement for zinc and could be at risk for marginal zinc deficiency. Zinc is an essential component of proteins in the defense against oxidative stress and DNA damage repair. Specifically in the prostate, zinc...

Resource Type:

Dissertation

Full Text:

Wong, technicians Karin Hardin and Valerie Elias, and everybody who helped me before. I would also
Dietary soy and green tea in the prevention of prostate cancer

Creator:

Hsu, Anna

Abstract:

Prostate cancer risk is significantly lower in Asian countries compared to the US, which has prompted interest in the chemo-preventative action of dietary components such as soy and green tea commonly found in Asian diets, such as soy and green tea. Studies have suggested that soy isoflavones and green tea...

Resource Type:

Dissertation

Full Text:

would also like to thank Dr. Carmen Wong, Karin Hardin, John Clarke, Valerie Elias, Dr. Michelle Yan