Search Constraints

Start Over
Filtering by: Committee Member Karplus, P. Andrew Remove constraint Committee Member: Karplus, P. Andrew Advisor Ho, Pui Shing Remove constraint Advisor: Ho, Pui Shing

Search Results

  • Crystal structures of DNA four-way junctions

    Creator:
    Eichman, Brandt F.
    Abstract:
    DNA four-way junctions (also known as Holliday junctions) are the primary structural intermediate during recombination, an important process responsible for biological evolution and maintenance of genomes. These junctions arise from the assembly of four nucleic acid strands to produce double-helical regions extending from a central point. Although much progress has...
    Resource Type:
    Dissertation
    Full Text:
    would also like to thank Dr. P. Andrew Karplus, as well as the rest of my committee for their helpful

  • Macromolecular halogen bonds

    Creator:
    Voth, Andrea Regier
    Abstract:
    The halogen bond is a non-covalent, stabilizing interaction analogous to a hydrogen bond in which an anisotropically polarized halogen atom interacts electrostatically with a Lewis base. Until very recently, the ability of halogens to form these stabilizing interactions in biological macromolecules was all but unknown, but examples of halogen bonding...
    Resource Type:
    Dissertation
    Full Text:
    bearable. Elsewhere in the department, thanks to Dr. P. Andrew Karplus for his dedicated teaching and

  • Analyses of noncanonical DNA structures

    Creator:
    Khuu, Patricia A.
    Abstract:
    The structural polymorphic nature of DNA has been long been recognized since the model of the right-handed B-DNA duplex proposed by James Watson and Francis Crick was accepted. Its malleability is thought to be critical in protein recognition and manipulation. In particular, it can form Holliday junctions, four-way DNA structural...
    Resource Type:
    Dissertation
    Full Text:
    P. Shing Ho, I thank my mentor, Dr. P. Shing Ho, for his support and guidance and, particularly