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Stabilization of Z-DNA by demethylation of thymine bases : a crystallization and thermo-dynamic study of d(m⁵CGUAm⁵CG)

Creator:

Zhou, Guangwen

Resource Type:

Dissertation

Full Text:

: a crystallization and thermo-dynamic study of d(m⁵CGUAm⁵CG) AN ABSTRACT OF THE THESIS OF Guangwen
Controlling DNA packing in crystals

Creator:

Mooers, Blaine H. M.

Resource Type:

Dissertation

Full Text:

of DNA oligonucleotides are a rich source of information about the conformation of DNA. However
The effect of cytosine methylation on DNA structure

Creator:

Vargason, Jeffrey M.

Abstract:

DNA methylation is common in prokaryotes and eukaryotes and has been implicated in various biological roles including gene silencing, X-chromosome inactivation, and genomic imprinting. 5-methylcytosine the "fifth base" of the genetic code comprises 1-3% of the human genome and is primarily found on cytosines within the context of the CpG...

Resource Type:

Dissertation

Full Text:

diffraction. 5-methylcytosine induces a novel conformation in the structure of duplex DNA. This conformation
Studies on the hydrophobic effect and its contribution to the stability, crystallization, and helix packing of Z-DNA

Creator:

Kagawa, Todd F.

Abstract:

The studies presented here use the B- to Z-DNA transition and Z-DNA crystallization as model systems to determine the contribution of solvent interactions to macromolecular structures. The substituent groups of naturally occurring and modified nucleotide bases affect the hydration and thus the stability of right-handed B-DNA and left-handed Z-DNA. The...

Resource Type:

Dissertation

Full Text:

the lattice is a direct measure of the DNA-DNA interactions at the surface of the crystal. Redacted