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Filtering by: Creator Payne, Loretta M. Remove constraint Creator: Payne, Loretta M. Advisor Hruby, Dennis E. Remove constraint Advisor: Hruby, Dennis E. Degree Field Molecular and Cellular Biology Remove constraint Degree Field: Molecular and Cellular Biology

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  • Vaccinia virus I7L core protein proteinase

    Creator:
    Byrd, Chelsea M.
    Abstract:
    Vaccinia virus (VV) is a large double-stranded DNA virus that is a prototypic member of the orthopoxvirus family. Previous works has showed that three of the major structural proteins found within the mature VV virion core 4a, 4b, and 25K are produced from higher molecular weight precursors at late times...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Chelsea M. Byrd for the

  • Fatty acylation of Vaccinia virus proteins : dual myristylation and palmitylation of the A-type inclusion protein

    Creator:
    Martin, Karen H.
    Abstract:
    The attachment of myristic acid to the N-terminal glycine residue of many eukaryotic and viral proteins is often essential for the acquisition of the protein's biological activity. Vaccinia virus (VV), the prototype member of the Poxviridae, expresses several myristylated proteins during the course of infection. Only one of these proteins,...
    Resource Type:
    Dissertation
    Full Text:
    protein did not fit the consensus sequence for N-myristylation (M-G-X-X-X- S/T/A/C/N), suggesting that it

  • Palmitylation of vaccinia virus proteins : identification of modification sites and biological relevance

    Creator:
    Grosenbach, Douglas W.
    Abstract:
    Vaccinia virus encodes at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through thioester linkage to cysteine residues. This is referred to as palmitylation of proteins. The purpose of this work was to gain an understanding of palmitylation, focusing on what defined...
    Resource Type:
    Dissertation
    Full Text:
    Golgi and the trans-Golgi network (C, M, T, and TGN respectively). The major stages of the virus life