Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Thomas, Dennis Advisor Hruby, Dennis E. File Format application/pdf

Characterization of vaccinia virus A12L protein : its proteolysis and functional analyses in virus replication

Creator:

Yang, Su Jung

Abstract:

In order to produce infectious virus progeny, vaccinia virus (VV) undergoes morphogenic proteolysis to regulate the structural rearrangements of virus particles. Several of the major structural precursor proteins of VV are cleaved at a conserved Ala-Gly-X (where X is any amino acid) motif by the VV I7L core protein proteinase...

Resource Type:

Dissertation

Full Text:

: Dr. Dennis E. Hruby In order to produce infectious virus progeny, vaccinia virus (VV
Structure-function analysis of the vaccinia virus I7L proteinase

Creator:

Moerdyk, Megan J.

Abstract:

Vaccinia virus is the prototypic member of the Orthopoxvirus genus. It undergoes a complex replication process where a key step in the transition from immature virion to intracellular mature virion is the cleavage of the major core protein precursors. The product of the I7L open reading frame (ORF) is a...

Resource Type:

Masters Thesis

Full Text:

approved: ______________________________________________________________ Dennis E. Hruby