Index Catalog // ScholarsArchive@OSU

Molecular genetic analysis of vaccinia virus genes which confer resistance to alpha-amanitin

Creator:: Tamin, Azaibi
Abstract:: Several laboratories have shown that the VV replication cycle is dependent on the host cell nucleus. The basic biological observation is that if the host cell nucleus is physically removed by cytochalasin B-mediated enucleation, functionally inactivated by UV-irradiation, or selectively blocked with a-amanitin, the results are the same: W is...
Resource Type:: Dissertation
Full Text:: M. biology in charge of major Redacted for Privacy C rman of Department of Microbiology Redacted

The regulation of a vaccinia virus late gene required for morphogenesis

Creator:: Miner, Jeffery N.
Abstract:: Vaccinia virus gene expression is characterized by tight temporal regulation. Viral early transcription begins within the cytoplasm upon infection; three hours later, early genes are repressed, DNA replication occurs and late gene expression commences. As an approach toward understanding the mechanisms governing vaccinia late gene expression, I have undertaken an...
Resource Type:: Dissertation
Full Text:: requires hard work and enthusiasm. The research technicians of the Hruby lab; Christine Franke, Lisa

Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

Creator:: Child, Stephanie J.
Abstract:: Vaccinia virus (VV), the prototype member of the orthopoxvirus family, is a large virus of complex morphology which contains a 191 Kbp double-stranded DNA genome whose expression is tightly regulated in a temporal fashion during viral replication. The regulation of gene expression can be exerted at various of levels, including...
Resource Type:: Dissertation
Full Text:: infinite enthusiasm for science and life inspired me, and whose friendship heartened me; to Christine

Proteolytic maturation of vaccinia virus structural proteins

Creator:: VanSlyke, Judy K.
Abstract:: Vaccinia virus (VV) is a large DNA virus belonging to the Orthopoxvirus family. The viral replicative life cycle takes place solely within the cytoplasm of a mammalian host cell. The VV genome contains 196 open reading frames which are expressed in a highly regulated and temporal fashion in order to...
Resource Type:: Dissertation
Full Text:: , especially Christine Franke for sharing her technical expertise and knowledge; Walt Hodges for his guidance

Post-translational modifications of vaccinia virus proteins : molecular analysis of the myristylated L1R gene produc

Creator:: Ravanello, Monica P. G.
Resource Type:: Dissertation
Full Text:: Protein - C - Ethanolamine - P Glycan Inositol PR R1, R2 , alkyl/acyl groups; P, phosphate 2

Fatty acylation of Vaccinia virus proteins : dual myristylation and palmitylation of the A-type inclusion protein

Creator:: Martin, Karen H.
Abstract:: The attachment of myristic acid to the N-terminal glycine residue of many eukaryotic and viral proteins is often essential for the acquisition of the protein's biological activity. Vaccinia virus (VV), the prototype member of the Poxviridae, expresses several myristylated proteins during the course of infection. Only one of these proteins,...
Resource Type:: Dissertation
Full Text:: protein did not fit the consensus sequence for N-myristylation (M-G-X-X-X- S/T/A/C/N), suggesting that it

The rpsL gene and streptomycin resistance in Streptococcus gordonii and Streptococcus pyogenes

Creator:: Vidyasanker, Radhika
Abstract:: Streptomycin resistance in both gram-positive and gram-negative bacteria is usually caused by a single mutation in the rpsL gene. The rpsL gene encodes the S12 protein of the ribosomal complex. The rpsL genes of various bacteria have consensus regions in their sequences. Primers were designed from these consensus pockets and...
Resource Type:: Masters Thesis
Full Text:: enthusiasm during the study. I thank Christine Franke for all the timely suggestions. I thank Dawn

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Creator:: Myscofski, Dawn M.
Abstract:: Streptococcus gordonii (S. gordonii) is being developed as a Gram-positive expression vector for the expression of heterologous proteins. This bacterial expression system takes advantage of the natural pathway of protein export and anchoring on the surface of the bacterium. The expression of heterologous proteins relies on the homologous recombination of...
Resource Type:: Dissertation
Full Text:: from the contaminating medium components, a histidine tag was added to either the N or the C-terminus

Evaluation of a potential Chylamydia psittaci vaccine candidate using recombinant vaccinia virus encoding the infection-specific C. psittaci GPIC proteins IncA and TroA

Creator:: Werth, Eric P.
Abstract:: Members of the family Chlamydiae cause a wide range of diseases. Chlamydia trachomatis and C. pneumoniae are most commonly associated with human disease. C. psittaci and C. pecorum are largely animal pathogens, although C. psittaci can cause pneumonia in the elderly and immunocompromised. A vaccine against these pathogens is desirable,...
Resource Type:: Masters Thesis
Full Text:: Chiamydiapsittaci Vaccine Candidate using Recombinant Vaccinia Virus Encoding the Infection-specific C. psittaci

Identification and analysis of vaccinia virus acylproteins

Creator:: Hansen, Scott G.
Abstract:: Vaccinia virus (VV) encodes at least six proteins that are modified by the addition of a 14-carbon saturated fatty acid through an amide linkage and at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through linkage to cysteine residues. These post-translational modifications...
Resource Type:: Dissertation
Full Text:: research labs including Kevin Jones, Hal Jones, Tove Bolkin, and Christine Franke have all been the people

ScholarsArchive@OSU

Molecular genetic analysis of vaccinia virus genes which confer resistance to alpha-amanitin

The regulation of a vaccinia virus late gene required for morphogenesis

Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

Proteolytic maturation of vaccinia virus structural proteins

Post-translational modifications of vaccinia virus proteins : molecular analysis of the myristylated L1R gene produc

Fatty acylation of Vaccinia virus proteins : dual myristylation and palmitylation of the A-type inclusion protein

The rpsL gene and streptomycin resistance in Streptococcus gordonii and Streptococcus pyogenes

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Evaluation of a potential Chylamydia psittaci vaccine candidate using recombinant vaccinia virus encoding the infection-specific C. psittaci GPIC proteins IncA and TroA

Identification and analysis of vaccinia virus acylproteins

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