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Creator:: Martin, Karen H.
Abstract:: The attachment of myristic acid to the N-terminal glycine residue of many eukaryotic and viral proteins is often essential for the acquisition of the protein's biological activity. Vaccinia virus (VV), the prototype member of the Poxviridae, expresses several myristylated proteins during the course of infection. Only one of these proteins,...
Resource Type:: Dissertation
Full Text:: 4 ml with hypotonic buffer and centrifuged at 33,000 rpm for 1 h at 4°C. The pellet (P100) was

Creator:: Blouch, Robert Edward
Abstract:: L1R, a myristylated late gene product of vaccinia virus, is essential for formation of infectious intracellular mature virions (IMV). In its absence, only viral particles arrested at an immature stage are detected and no infectious progeny virus are produced. Previous studies have shown that the L1R protein is exclusively associated...
Resource Type:: Masters Thesis
Full Text:: ................................................ 18 4. RESULTS ................................................................. 20 Characterization

Creator:: Grosenbach, Douglas W.
Abstract:: Vaccinia virus encodes at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through thioester linkage to cysteine residues. This is referred to as palmitylation of proteins. The purpose of this work was to gain an understanding of palmitylation, focusing on what defined...
Resource Type:: Dissertation
Full Text:: 1.3.2 Palmitylproteins .................................................................20 1 .4

Creator:: Hansen, Scott G.
Abstract:: Vaccinia virus (VV) encodes at least six proteins that are modified by the addition of a 14-carbon saturated fatty acid through an amide linkage and at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through linkage to cysteine residues. These post-translational modifications...
Resource Type:: Dissertation
Full Text:: % of the protein-bound myristate was rapidly (<4 h) elongated to palmitate in these cells, and the

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