Index Catalog // ScholarsArchive@OSU

Investigations into the Mechanism of Action of Dengue Virus Inhibitor Compounds

Creator:: Schneider, Christine A.
Abstract:: Several compounds have been recently identified which are effective against dengue virus, a tropical arbovirus highly prevalent in southeast Asia and central America. Initial intrinsic fluorescence characterization of the mechanism of action of compound B reveals binding affinity to the dengue capsid protein. A molecular beacon unwinding assay and malachite...
Resource Type:: Honors College Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Christine A

The rpsL gene and streptomycin resistance in Streptococcus gordonii and Streptococcus pyogenes

Creator:: Vidyasanker, Radhika
Abstract:: Streptomycin resistance in both gram-positive and gram-negative bacteria is usually caused by a single mutation in the rpsL gene. The rpsL gene encodes the S12 protein of the ribosomal complex. The rpsL genes of various bacteria have consensus regions in their sequences. Primers were designed from these consensus pockets and...
Resource Type:: Masters Thesis
Full Text:: RESISTANCE IN STREPTOCOCCUS GORDONII AND STREPTOCOCCUS PYOGENES. Abstract approved: Dennis E. Hruby

Molecular genetic analysis of vaccinia virus genes which confer resistance to alpha-amanitin

Creator:: Tamin, Azaibi
Abstract:: Several laboratories have shown that the VV replication cycle is dependent on the host cell nucleus. The basic biological observation is that if the host cell nucleus is physically removed by cytochalasin B-mediated enucleation, functionally inactivated by UV-irradiation, or selectively blocked with a-amanitin, the results are the same: W is...
Resource Type:: Dissertation
Full Text:: Dr. Dennis E. Hruby Several laboratories have shown that the VV replication cycle is dependent on

Fatty acylation of Vaccinia virus proteins : dual myristylation and palmitylation of the A-type inclusion protein

Creator:: Martin, Karen H.
Abstract:: The attachment of myristic acid to the N-terminal glycine residue of many eukaryotic and viral proteins is often essential for the acquisition of the protein's biological activity. Vaccinia virus (VV), the prototype member of the Poxviridae, expresses several myristylated proteins during the course of infection. Only one of these proteins,...
Resource Type:: Dissertation
Full Text:: , Christine A. Franke, and Dennis E. Hruby 16 SUMMARY Previous studies have shown that at least 3

Proteolytic maturation of vaccinia virus structural proteins

Creator:: VanSlyke, Judy K.
Abstract:: Vaccinia virus (VV) is a large DNA virus belonging to the Orthopoxvirus family. The viral replicative life cycle takes place solely within the cytoplasm of a mammalian host cell. The VV genome contains 196 open reading frames which are expressed in a highly regulated and temporal fashion in order to...
Resource Type:: Dissertation
Full Text:: Proteins Abstract approved: Dr. Dennis E. Hruby Vaccinia virus (VV) is a large DNA virus belonging to

Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

Creator:: Child, Stephanie J.
Abstract:: Vaccinia virus (VV), the prototype member of the orthopoxvirus family, is a large virus of complex morphology which contains a 191 Kbp double-stranded DNA genome whose expression is tightly regulated in a temporal fashion during viral replication. The regulation of gene expression can be exerted at various of levels, including...
Resource Type:: Dissertation
Full Text:: ADP-RIBOSYLATION OF VIRAL PROTEINS Stephanie J. Child, Christine A. Franke, and Dennis E. Hruby 16

The regulation of a vaccinia virus late gene required for morphogenesis

Creator:: Miner, Jeffery N.
Abstract:: Vaccinia virus gene expression is characterized by tight temporal regulation. Viral early transcription begins within the cytoplasm upon infection; three hours later, early genes are repressed, DNA replication occurs and late gene expression commences. As an approach toward understanding the mechanisms governing vaccinia late gene expression, I have undertaken an...
Resource Type:: Dissertation
Full Text:: Morphogenesis Abstract approved: Redacted for Priv/ ac)/ Dr. Dennis E. Hruby Vaccinia virus gene expression is

Post-translational modifications of vaccinia virus proteins : molecular analysis of the myristylated L1R gene produc

Creator:: Ravanello, Monica P. G.
Resource Type:: Dissertation
Full Text:: . Ravanello, Christine A. Franke and Dennis E. Hruby 17 SUMMARY The VV L1R gene product is a late

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Creator:: Myscofski, Dawn M.
Abstract:: Streptococcus gordonii (S. gordonii) is being developed as a Gram-positive expression vector for the expression of heterologous proteins. This bacterial expression system takes advantage of the natural pathway of protein export and anchoring on the surface of the bacterium. The expression of heterologous proteins relies on the homologous recombination of...
Resource Type:: Dissertation
Full Text:: - positive Bacterial Vector, Streptococcus gordonii. Abstract approved: Dennis E. Hruby Streptococcus

Identification and analysis of vaccinia virus acylproteins

Creator:: Hansen, Scott G.
Abstract:: Vaccinia virus (VV) encodes at least six proteins that are modified by the addition of a 14-carbon saturated fatty acid through an amide linkage and at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through linkage to cysteine residues. These post-translational modifications...
Resource Type:: Dissertation
Full Text:: of Vaccinia Virus Acylproteins Abstract approved: Dennis E. Hruby Vaccinia virus (VV) encodes at

ScholarsArchive@OSU

Investigations into the Mechanism of Action of Dengue Virus Inhibitor Compounds

The rpsL gene and streptomycin resistance in Streptococcus gordonii and Streptococcus pyogenes

Molecular genetic analysis of vaccinia virus genes which confer resistance to alpha-amanitin

Fatty acylation of Vaccinia virus proteins : dual myristylation and palmitylation of the A-type inclusion protein

Proteolytic maturation of vaccinia virus structural proteins

Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

The regulation of a vaccinia virus late gene required for morphogenesis

Post-translational modifications of vaccinia virus proteins : molecular analysis of the myristylated L1R gene produc

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Identification and analysis of vaccinia virus acylproteins

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