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Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

Creator:: Child, Stephanie J.
Abstract:: Vaccinia virus (VV), the prototype member of the orthopoxvirus family, is a large virus of complex morphology which contains a 191 Kbp double-stranded DNA genome whose expression is tightly regulated in a temporal fashion during viral replication. The regulation of gene expression can be exerted at various of levels, including...
Resource Type:: Dissertation
Full Text:: Virus Core Proteins by ADP-ribosylation by Stephanie J. Child A THESIS submitted to Oregon State

Structure-function analysis of the vaccinia virus I7L proteinase

Creator:: Moerdyk, Megan J.
Abstract:: Vaccinia virus is the prototypic member of the Orthopoxvirus genus. It undergoes a complex replication process where a key step in the transition from immature virion to intracellular mature virion is the cleavage of the major core protein precursors. The product of the I7L open reading frame (ORF) is a...
Resource Type:: Masters Thesis
Full Text:: OF Megan J. Moerdyk for the degree of Master of Science in Microbiology presented on December

Vaccinia virus I7L core protein proteinase

Creator:: Byrd, Chelsea M.
Abstract:: Vaccinia virus (VV) is a large double-stranded DNA virus that is a prototypic member of the orthopoxvirus family. Previous works has showed that three of the major structural proteins found within the mature VV virion core 4a, 4b, and 25K are produced from higher molecular weight precursors at late times...
Resource Type:: Dissertation
Full Text:: virion 4a, 4b, and 25K through pulse chase experiments. Figure 1.2 (VanSlyke & Hruby, 1994) is a pulse

Characterization of vaccinia virus A12L protein : its proteolysis and functional analyses in virus replication

Creator:: Yang, Su Jung
Abstract:: In order to produce infectious virus progeny, vaccinia virus (VV) undergoes morphogenic proteolysis to regulate the structural rearrangements of virus particles. Several of the major structural precursor proteins of VV are cleaved at a conserved Ala-Gly-X (where X is any amino acid) motif by the VV I7L core protein proteinase...
Resource Type:: Dissertation
Full Text:: and pulse chase of A12L protein. · · · · · · · · · · · · · 51 2.3 Proteolysis of A12L

Proteolytic maturation of vaccinia virus structural proteins

Creator:: VanSlyke, Judy K.
Abstract:: Vaccinia virus (VV) is a large DNA virus belonging to the Orthopoxvirus family. The viral replicative life cycle takes place solely within the cytoplasm of a mammalian host cell. The VV genome contains 196 open reading frames which are expressed in a highly regulated and temporal fashion in order to...
Resource Type:: Dissertation
Full Text:: [ ....\ earlyReplication Machinery '411. .RNA virokines ... reedy virion proteins j , .. Um:sating II ' s I I Viral DNA

Regulation of late gene expression in vaccinia virus

Creator:: Weinrich, Scott L.
Abstract:: The prototypal poxvirus vaccinia is a cytoplasmic-replicating DNA virus which contains a large genome with the capacity to encode 200 polypeptides. Tight temporal regulation coordinates the expression of this large number of genes throughout a relatively short replication cycle. As a first step towards identifying and understanding the regulatory mechanisms...
Resource Type:: Dissertation
Full Text:: synthesized in VV-infected BSC-40 cells Figure 11.2 Pulse-chase analysis of polypeptides 25 synthesized in VV

Post-translational modifications of vaccinia virus proteins : molecular analysis of the myristylated L1R gene produc

Creator:: Ravanello, Monica P. G.
Resource Type:: Dissertation
Full Text:: Electron microscopy analysis of vlacOL1R. 103 IV.7 Pulse-chase analysis of major core proteins p4a, p4b

Proteolytic maturation of vaccinia virus virion-associated proteins : analysis of substrate determinants

Creator:: Lee, Peiyu
Resource Type:: Dissertation
Full Text:: chimeric protein by an epitope-specific monoclonal antibody. Results of the pulse-chase, directed genetics

Proteolytic maturation of Vaccinia virus structural proteins : enzyme and substrate analysis

Creator:: Whitehead, Stephen S.
Resource Type:: Dissertation
Full Text:: AG*A cleavage motif 11.2 Immunoprecipitation analysis of DNAP and HR proteins 28 II.3 Pulse-chase

Replication of vaccinia virus in the presence of 1,10-phenanthroline

Creator:: ApRoberts, Robyn E.
Abstract:: 1,10-phenanthroline and its non-chelating isomer, 1,7-phenanthroline were used to inhibit the replication of vaccinia virus (VV). Serial passage of VV in the presence of various concentrations of either 1,10-phenanthroline or 1,7-phenanthroline was carried out. No drug resistant mutants were isolated, suggesting that the observed inhibition was due to a cellular...
Resource Type:: Masters Thesis
Full Text:: 15 IV.1 Graphic Representation of a One-step Growth Curve Analysis 32 IV.2 Pulse-chase

ScholarsArchive@OSU

Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

Structure-function analysis of the vaccinia virus I7L proteinase

Vaccinia virus I7L core protein proteinase

Characterization of vaccinia virus A12L protein : its proteolysis and functional analyses in virus replication

Proteolytic maturation of vaccinia virus structural proteins

Regulation of late gene expression in vaccinia virus

Post-translational modifications of vaccinia virus proteins : molecular analysis of the myristylated L1R gene produc

Proteolytic maturation of vaccinia virus virion-associated proteins : analysis of substrate determinants

Proteolytic maturation of Vaccinia virus structural proteins : enzyme and substrate analysis

Replication of vaccinia virus in the presence of 1,10-phenanthroline

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