Index Catalog // ScholarsArchive@OSU

Creator:: VanSlyke, Judy K.
Abstract:: Vaccinia virus (VV) is a large DNA virus belonging to the Orthopoxvirus family. The viral replicative life cycle takes place solely within the cytoplasm of a mammalian host cell. The VV genome contains 196 open reading frames which are expressed in a highly regulated and temporal fashion in order to...
Resource Type:: Dissertation
Full Text:: Mathews, William Dougherty, Peter Bottom ley, and Carol Rivin for their scientific guidance and

Creator:: Martin, Karen H.
Abstract:: The attachment of myristic acid to the N-terminal glycine residue of many eukaryotic and viral proteins is often essential for the acquisition of the protein's biological activity. Vaccinia virus (VV), the prototype member of the Poxviridae, expresses several myristylated proteins during the course of infection. Only one of these proteins,...
Resource Type:: Dissertation
Full Text:: Meints, George Rohrmann, Chris Mathews, and Barry Sherr. I have had the unique opportunity of working

Creator:: Grosenbach, Douglas W.
Abstract:: Vaccinia virus encodes at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through thioester linkage to cysteine residues. This is referred to as palmitylation of proteins. The purpose of this work was to gain an understanding of palmitylation, focusing on what defined...
Resource Type:: Dissertation
Full Text:: my graduate committee, Chris Mathews, George Rohrmann, Frank Moore and Bruce Coblentz. Every

Creator:: Black, Margaret E.
Abstract:: Thymidine kinase is a key enzyme in the nucleotide salvage pathway, catalyzing the production of dTMP from thymidine and ATP. In order to identify the structural features of the TK protein and/or primary amino acid sequences which contribute to the catalytic and regulatory activities of this enzyme, an in vitro...
Resource Type:: Dissertation
Full Text:: especially thank him for taking the time to listen, a rare trait in scientists these days. Dr. Chris Mathews

Creator:: Roseman, Nancy A.
Abstract:: Replication of vaccinia virus in the cytoplasm of the infected cell occurs under the direction of virally encoded gene products. Expression of approximately 200 viral genes follows a highly regulated temporal scheme which can be followed biochemically and morphologically during the assembly process. In order to dissect this complex genetic...
Resource Type:: Dissertation
Full Text:: not encode a thermolabile subunit of ribonucleotide reductase (data not shown, Slabaugh and Mathews

Creator:: Lee, Peiyu
Resource Type:: Dissertation
Full Text:: , potyviruses, and tymoviruses, have been identified and well characterized (reviewed by Kay and Dunn, 1990

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