Index Catalog // ScholarsArchive@OSU

Identification of Small Molecule Inhibitors of the Staphylococcus aureus Sortase A Enzyme

Creator:: Bateman, Katherine B.
Abstract:: The Sortase A (SrtA) enzyme is a potential target for a new class of anti-infective drugs because it is responsible for anchoring virulence factors to the surface of pathogenic, Gram-positive bacteria such as Staphylococcus aureus. High throughput screening yielded low molecular weight compounds that inhibit purified SrtA from S. aureus....
Resource Type:: Honors College Thesis
Full Text:: , 2008. Title: Identification of Small Molecule Inhibitors of the Staphylococcus aureus Sortase A

Evaluation of a potential Chylamydia psittaci vaccine candidate using recombinant vaccinia virus encoding the infection-specific C. psittaci GPIC proteins IncA and TroA

Creator:: Werth, Eric P.
Abstract:: Members of the family Chlamydiae cause a wide range of diseases. Chlamydia trachomatis and C. pneumoniae are most commonly associated with human disease. C. psittaci and C. pecorum are largely animal pathogens, although C. psittaci can cause pneumonia in the elderly and immunocompromised. A vaccine against these pathogens is desirable,...
Resource Type:: Masters Thesis
Full Text:: Master of Science in Microbiology presented on June 27. 2001 Title: Evaluation of a Potential

Investigation of the roles of viral proteinases in the vaccinia virus life cycle

Creator:: Page, Jessica M.
Abstract:: An inducible, mutant virus, designated vvtetO:I7L/G1L, was used to study the morphogenic proteolysis step of the vaccinia virus life cycle. The vvtetO:I7L/G1L controlled the expression of two genes, I7L, a cysteine proteinase, and G1L, a putative metalloproteinase. These proteins are involved in the maturation of viral core proteins, p4a, p4b,...
Resource Type:: Honors College Thesis
Full Text:: , I7L, a cysteine proteinase, and G1L, a putative metalloproteinase. These proteins are involved in the

Disulphide bond formation is essential for vaccinia virus late protein L1R function and for production of infectious progeny

Creator:: Blouch, Robert Edward
Abstract:: L1R, a myristylated late gene product of vaccinia virus, is essential for formation of infectious intracellular mature virions (IMV). In its absence, only viral particles arrested at an immature stage are detected and no infectious progeny virus are produced. Previous studies have shown that the L1R protein is exclusively associated...
Resource Type:: Masters Thesis
Full Text:: Progeny. approved: DennisE. Hruby LIR, a myristylated late gene product of vaccinia virus, is essential

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Creator:: Myscofski, Dawn M.
Abstract:: Streptococcus gordonii (S. gordonii) is being developed as a Gram-positive expression vector for the expression of heterologous proteins. This bacterial expression system takes advantage of the natural pathway of protein export and anchoring on the surface of the bacterium. The expression of heterologous proteins relies on the homologous recombination of...
Resource Type:: Dissertation
Full Text:: gordonii (S. gordonil) is being developed as a Gram-positive expression vector for the expression of

Characterization of vaccinia virus A12L protein : its proteolysis and functional analyses in virus replication

Creator:: Yang, Su Jung
Abstract:: In order to produce infectious virus progeny, vaccinia virus (VV) undergoes morphogenic proteolysis to regulate the structural rearrangements of virus particles. Several of the major structural precursor proteins of VV are cleaved at a conserved Ala-Gly-X (where X is any amino acid) motif by the VV I7L core protein proteinase...
Resource Type:: Dissertation
Full Text:: the major structural precursor proteins of VV are cleaved at a conserved Ala-Gly-X (where X is any

Structure-function analysis of the vaccinia virus I7L proteinase

Creator:: Moerdyk, Megan J.
Abstract:: Vaccinia virus is the prototypic member of the Orthopoxvirus genus. It undergoes a complex replication process where a key step in the transition from immature virion to intracellular mature virion is the cleavage of the major core protein precursors. The product of the I7L open reading frame (ORF) is a...
Resource Type:: Masters Thesis
Full Text:: Vaccinia virus is the prototypic member of the Orthopoxvirus genus. It undergoes a complex replication

Vaccinia virus I7L core protein proteinase

Creator:: Byrd, Chelsea M.
Abstract:: Vaccinia virus (VV) is a large double-stranded DNA virus that is a prototypic member of the orthopoxvirus family. Previous works has showed that three of the major structural proteins found within the mature VV virion core 4a, 4b, and 25K are produced from higher molecular weight precursors at late times...
Resource Type:: Dissertation
Full Text:: : Vaccinia Virus 17L Core Protein Proteinase Abstract approved: Dr. Dennis E. Vaccinia virus (VV) is a

Advances in expression of heterologous protein products by Streptococcus gordonii

Creator:: Warren, Travis Kent
Abstract:: Streptococcus gordonii is a bacterial species that naturally colonizes the oral cavity of most healthy humans. It resides in the mouth as an adherent to dental surfaces and, with few exceptions, does not cause disease in individuals it inhabits. It possesses qualities that encourage its use as a vector to...
Resource Type:: Dissertation
Full Text:: : ______________________________________ Dr. Dennis E. Hruby Streptococcus gordonii is a bacterial species that naturally colonizes

Identification and analysis of vaccinia virus acylproteins

Creator:: Hansen, Scott G.
Abstract:: Vaccinia virus (VV) encodes at least six proteins that are modified by the addition of a 14-carbon saturated fatty acid through an amide linkage and at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through linkage to cysteine residues. These post-translational modifications...
Resource Type:: Dissertation
Full Text:: least six proteins that are modified by the addition of a 14-carbon saturated fatty acid through an

ScholarsArchive@OSU

Identification of Small Molecule Inhibitors of the Staphylococcus aureus Sortase A Enzyme

Evaluation of a potential Chylamydia psittaci vaccine candidate using recombinant vaccinia virus encoding the infection-specific C. psittaci GPIC proteins IncA and TroA

Investigation of the roles of viral proteinases in the vaccinia virus life cycle

Disulphide bond formation is essential for vaccinia virus late protein L1R function and for production of infectious progeny

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Characterization of vaccinia virus A12L protein : its proteolysis and functional analyses in virus replication

Structure-function analysis of the vaccinia virus I7L proteinase

Vaccinia virus I7L core protein proteinase

Advances in expression of heterologous protein products by Streptococcus gordonii

Identification and analysis of vaccinia virus acylproteins

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