Index Catalog // ScholarsArchive@OSU

Investigations into the Mechanism of Action of Dengue Virus Inhibitor Compounds

Creator:: Schneider, Christine A.
Abstract:: Several compounds have been recently identified which are effective against dengue virus, a tropical arbovirus highly prevalent in southeast Asia and central America. Initial intrinsic fluorescence characterization of the mechanism of action of compound B reveals binding affinity to the dengue capsid protein. A molecular beacon unwinding assay and malachite...
Resource Type:: Honors College Thesis
Full Text:: virus is a major emerging infectious disease, necessitating an increase in research efforts to create

Investigation of the roles of viral proteinases in the vaccinia virus life cycle

Creator:: Page, Jessica M.
Abstract:: An inducible, mutant virus, designated vvtetO:I7L/G1L, was used to study the morphogenic proteolysis step of the vaccinia virus life cycle. The vvtetO:I7L/G1L controlled the expression of two genes, I7L, a cysteine proteinase, and G1L, a putative metalloproteinase. These proteins are involved in the maturation of viral core proteins, p4a, p4b,...
Resource Type:: Honors College Thesis
Full Text:: research, especially Dr. Dennis Hruby, Megan Moerdyk, Dr. Chelsea Byrd, Kady Honeychurch, Jennifer Yoder

Regulation of late gene expression in vaccinia virus

Creator:: Weinrich, Scott L.
Abstract:: The prototypal poxvirus vaccinia is a cytoplasmic-replicating DNA virus which contains a large genome with the capacity to encode 200 polypeptides. Tight temporal regulation coordinates the expression of this large number of genes throughout a relatively short replication cycle. As a first step towards identifying and understanding the regulatory mechanisms...
Resource Type:: Dissertation
Full Text:: -replicating DNA virus which contains a large genome with the capacity to encode 200 polypeptides. Tight

Proteolytic maturation of vaccinia virus structural proteins

Creator:: VanSlyke, Judy K.
Abstract:: Vaccinia virus (VV) is a large DNA virus belonging to the Orthopoxvirus family. The viral replicative life cycle takes place solely within the cytoplasm of a mammalian host cell. The VV genome contains 196 open reading frames which are expressed in a highly regulated and temporal fashion in order to...
Resource Type:: Dissertation
Full Text:: of a mammalian host cell. The VV genome contains 196 open reading frames which are expressed in a

Molecular genetic analysis of vaccinia virus genes which confer resistance to alpha-amanitin

Creator:: Tamin, Azaibi
Abstract:: Several laboratories have shown that the VV replication cycle is dependent on the host cell nucleus. The basic biological observation is that if the host cell nucleus is physically removed by cytochalasin B-mediated enucleation, functionally inactivated by UV-irradiation, or selectively blocked with a-amanitin, the results are the same: W is...
Resource Type:: Dissertation
Full Text:: HindIII N/M region of the genome by the use of marker rescue techniques [E.C. Villarreal and D.E. Hruby

Host cell nuclear involvement in vaccinia virus replication

Creator:: Villarreal, Elcira C.
Abstract:: It was previously shown that vaccinia virus is unable to complete its replicative cycle in cells that have been subjected to cytochalasin-B mediated enucleation prior to infection. Likewise, in the presence of the drug α-amanitin, a potent inhibitor of host RNA polymerase II but not of viral transcription, the replication...
Resource Type:: Dissertation
Full Text:: HindIII-N fragment, I sequenced this region of the genome using the Sanger dideoxynucleotide chain termi

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Creator:: Myscofski, Dawn M.
Abstract:: Streptococcus gordonii (S. gordonii) is being developed as a Gram-positive expression vector for the expression of heterologous proteins. This bacterial expression system takes advantage of the natural pathway of protein export and anchoring on the surface of the bacterium. The expression of heterologous proteins relies on the homologous recombination of...
Resource Type:: Dissertation
Full Text:: the homologous recombination of a plasmid into the genome of S. gordonii. The heterologous proteins

Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

Creator:: Child, Stephanie J.
Abstract:: Vaccinia virus (VV), the prototype member of the orthopoxvirus family, is a large virus of complex morphology which contains a 191 Kbp double-stranded DNA genome whose expression is tightly regulated in a temporal fashion during viral replication. The regulation of gene expression can be exerted at various of levels, including...
Resource Type:: Dissertation
Full Text:: morphology which contains a 191 Kbp double- stranded DNA genome whose expression is tightly regulated in a

Disulphide bond formation is essential for vaccinia virus late protein L1R function and for production of infectious progeny

Creator:: Blouch, Robert Edward
Abstract:: L1R, a myristylated late gene product of vaccinia virus, is essential for formation of infectious intracellular mature virions (IMV). In its absence, only viral particles arrested at an immature stage are detected and no infectious progeny virus are produced. Previous studies have shown that the L1R protein is exclusively associated...
Resource Type:: Masters Thesis
Full Text:: in AIDS patients. Poxvirus is the largest DNA viruses with a genome that encodes more than 200 gene

Proteolytic maturation of Vaccinia virus structural proteins : enzyme and substrate analysis

Creator:: Whitehead, Stephen S.
Resource Type:: Dissertation
Full Text:: retrovirus HIV genome expressing inactivated proteinase molecules failed to produce 5 infectious virion

ScholarsArchive@OSU

Investigations into the Mechanism of Action of Dengue Virus Inhibitor Compounds

Investigation of the roles of viral proteinases in the vaccinia virus life cycle

Regulation of late gene expression in vaccinia virus

Proteolytic maturation of vaccinia virus structural proteins

Molecular genetic analysis of vaccinia virus genes which confer resistance to alpha-amanitin

Host cell nuclear involvement in vaccinia virus replication

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

Disulphide bond formation is essential for vaccinia virus late protein L1R function and for production of infectious progeny

Proteolytic maturation of Vaccinia virus structural proteins : enzyme and substrate analysis

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