Index Catalog // ScholarsArchive@OSU

Identification of Small Molecule Inhibitors of the Staphylococcus aureus Sortase A Enzyme

Creator:: Bateman, Katherine B.
Abstract:: The Sortase A (SrtA) enzyme is a potential target for a new class of anti-infective drugs because it is responsible for anchoring virulence factors to the surface of pathogenic, Gram-positive bacteria such as Staphylococcus aureus. High throughput screening yielded low molecular weight compounds that inhibit purified SrtA from S. aureus....
Resource Type:: Honors College Thesis
Full Text:: Dennis Hruby The Sortase A (SrtA) enzyme is a potential target for a new class of anti-infective drugs

Advances in expression of heterologous protein products by Streptococcus gordonii

Creator:: Warren, Travis Kent
Abstract:: Streptococcus gordonii is a bacterial species that naturally colonizes the oral cavity of most healthy humans. It resides in the mouth as an adherent to dental surfaces and, with few exceptions, does not cause disease in individuals it inhabits. It possesses qualities that encourage its use as a vector to...
Resource Type:: Dissertation
Full Text:: : ______________________________________ Dr. Dennis E. Hruby Streptococcus gordonii is a bacterial species that naturally colonizes

The rpsL gene and streptomycin resistance in Streptococcus gordonii and Streptococcus pyogenes

Creator:: Vidyasanker, Radhika
Abstract:: Streptomycin resistance in both gram-positive and gram-negative bacteria is usually caused by a single mutation in the rpsL gene. The rpsL gene encodes the S12 protein of the ribosomal complex. The rpsL genes of various bacteria have consensus regions in their sequences. Primers were designed from these consensus pockets and...
Resource Type:: Masters Thesis
Full Text:: RESISTANCE IN STREPTOCOCCUS GORDONII AND STREPTOCOCCUS PYOGENES. Abstract approved: Dennis E. Hruby

Molecular genetic analysis of vaccinia virus genes which confer resistance to alpha-amanitin

Creator:: Tamin, Azaibi
Abstract:: Several laboratories have shown that the VV replication cycle is dependent on the host cell nucleus. The basic biological observation is that if the host cell nucleus is physically removed by cytochalasin B-mediated enucleation, functionally inactivated by UV-irradiation, or selectively blocked with a-amanitin, the results are the same: W is...
Resource Type:: Dissertation
Full Text:: Dr. Dennis E. Hruby Several laboratories have shown that the VV replication cycle is dependent on

Palmitylation of vaccinia virus proteins : identification of modification sites and biological relevance

Creator:: Grosenbach, Douglas W.
Abstract:: Vaccinia virus encodes at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through thioester linkage to cysteine residues. This is referred to as palmitylation of proteins. The purpose of this work was to gain an understanding of palmitylation, focusing on what defined...
Resource Type:: Dissertation
Full Text:: as well. I am grateful to Dennis Hruby not only for advising me through this course of study, but

Disulphide bond formation is essential for vaccinia virus late protein L1R function and for production of infectious progeny

Creator:: Blouch, Robert Edward
Abstract:: L1R, a myristylated late gene product of vaccinia virus, is essential for formation of infectious intracellular mature virions (IMV). In its absence, only viral particles arrested at an immature stage are detected and no infectious progeny virus are produced. Previous studies have shown that the L1R protein is exclusively associated...
Resource Type:: Masters Thesis
Full Text:: I would like to express my sincere appreciation to Dennis E. Hruby for his patience and guidance

Post-translational modifications of vaccinia virus proteins : molecular analysis of the myristylated L1R gene produc

Creator:: Ravanello, Monica P. G.
Resource Type:: Dissertation
Full Text:: L1R Ge Abstract approved: .6'17 Dr. Dennis E. Hruby Co-translational covalent attachment of

Biology of a constitutively-expressed vaccinia virus gene required for DNA replication

Creator:: Roseman, Nancy A.
Abstract:: Replication of vaccinia virus in the cytoplasm of the infected cell occurs under the direction of virally encoded gene products. Expression of approximately 200 viral genes follows a highly regulated temporal scheme which can be followed biochemically and morphologically during the assembly process. In order to dissect this complex genetic...
Resource Type:: Dissertation
Full Text:: . Dennis E. Hrub Replication of vaccinia virus in the cytoplasm of the infected cell occurs under the

Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

Creator:: Child, Stephanie J.
Abstract:: Vaccinia virus (VV), the prototype member of the orthopoxvirus family, is a large virus of complex morphology which contains a 191 Kbp double-stranded DNA genome whose expression is tightly regulated in a temporal fashion during viral replication. The regulation of gene expression can be exerted at various of levels, including...
Resource Type:: Dissertation
Full Text:: Core Proteins by ADP- ribosylation. Redacted for Privacy Abstract approved. - Dr. Dennis E. Hr

Identification and analysis of vaccinia virus acylproteins

Creator:: Hansen, Scott G.
Abstract:: Vaccinia virus (VV) encodes at least six proteins that are modified by the addition of a 14-carbon saturated fatty acid through an amide linkage and at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through linkage to cysteine residues. These post-translational modifications...
Resource Type:: Dissertation
Full Text:: of Vaccinia Virus Acylproteins Abstract approved: Dennis E. Hruby Vaccinia virus (VV) encodes at

ScholarsArchive@OSU

Identification of Small Molecule Inhibitors of the Staphylococcus aureus Sortase A Enzyme

Advances in expression of heterologous protein products by Streptococcus gordonii

The rpsL gene and streptomycin resistance in Streptococcus gordonii and Streptococcus pyogenes

Molecular genetic analysis of vaccinia virus genes which confer resistance to alpha-amanitin

Palmitylation of vaccinia virus proteins : identification of modification sites and biological relevance

Disulphide bond formation is essential for vaccinia virus late protein L1R function and for production of infectious progeny

Post-translational modifications of vaccinia virus proteins : molecular analysis of the myristylated L1R gene produc

Biology of a constitutively-expressed vaccinia virus gene required for DNA replication

Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

Identification and analysis of vaccinia virus acylproteins

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