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Advances in expression of heterologous protein products by Streptococcus gordonii

Creator:: Warren, Travis Kent
Abstract:: Streptococcus gordonii is a bacterial species that naturally colonizes the oral cavity of most healthy humans. It resides in the mouth as an adherent to dental surfaces and, with few exceptions, does not cause disease in individuals it inhabits. It possesses qualities that encourage its use as a vector to...
Resource Type:: Dissertation
Full Text:: Expression of Heterologous Protein Products by Streptococcus gordonii. Abstract approved

Characterization of vaccinia virus A12L protein : its proteolysis and functional analyses in virus replication

Creator:: Yang, Su Jung
Abstract:: In order to produce infectious virus progeny, vaccinia virus (VV) undergoes morphogenic proteolysis to regulate the structural rearrangements of virus particles. Several of the major structural precursor proteins of VV are cleaved at a conserved Ala-Gly-X (where X is any amino acid) motif by the VV I7L core protein proteinase...
Resource Type:: Dissertation
Full Text:: on December 22, 2006. Title: Characterization of Vaccinia Virus A12L Protein: Its Proteolysis

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Creator:: Myscofski, Dawn M.
Abstract:: Streptococcus gordonii (S. gordonii) is being developed as a Gram-positive expression vector for the expression of heterologous proteins. This bacterial expression system takes advantage of the natural pathway of protein export and anchoring on the surface of the bacterium. The expression of heterologous proteins relies on the homologous recombination of...
Resource Type:: Dissertation
Full Text:: Creation of an efficient protein expression and secretion

Disulphide bond formation is essential for vaccinia virus late protein L1R function and for production of infectious progeny

Creator:: Blouch, Robert Edward
Abstract:: L1R, a myristylated late gene product of vaccinia virus, is essential for formation of infectious intracellular mature virions (IMV). In its absence, only viral particles arrested at an immature stage are detected and no infectious progeny virus are produced. Previous studies have shown that the L1R protein is exclusively associated...
Resource Type:: Masters Thesis
Full Text:: Formation is Essential for Vaccinia Virus Late Protein LIR Function and for Production of Infectious

Fatty acylation of Vaccinia virus proteins : dual myristylation and palmitylation of the A-type inclusion protein

Creator:: Martin, Karen H.
Abstract:: The attachment of myristic acid to the N-terminal glycine residue of many eukaryotic and viral proteins is often essential for the acquisition of the protein's biological activity. Vaccinia virus (VV), the prototype member of the Poxviridae, expresses several myristylated proteins during the course of infection. Only one of these proteins,...
Resource Type:: Dissertation
Full Text:: Acylation of Vaccinia Virus Proteins: Dual Myristylation and Palmitylation of the A-type Inclusion Protein

Identification and analysis of vaccinia virus acylproteins

Creator:: Hansen, Scott G.
Abstract:: Vaccinia virus (VV) encodes at least six proteins that are modified by the addition of a 14-carbon saturated fatty acid through an amide linkage and at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through linkage to cysteine residues. These post-translational modifications...
Resource Type:: Dissertation
Full Text:: a protein so that we could identify and begin the characterization of new palmitylproteins

Palmitylation of vaccinia virus proteins : identification of modification sites and biological relevance

Creator:: Grosenbach, Douglas W.
Abstract:: Vaccinia virus encodes at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through thioester linkage to cysteine residues. This is referred to as palmitylation of proteins. The purpose of this work was to gain an understanding of palmitylation, focusing on what defined...
Resource Type:: Dissertation
Full Text:: biological relevance of protein palmitylation in the vaccinia virus life cycle. A systematic approach was

Proteolytic maturation of vaccinia virus structural proteins

Creator:: VanSlyke, Judy K.
Abstract:: Vaccinia virus (VV) is a large DNA virus belonging to the Orthopoxvirus family. The viral replicative life cycle takes place solely within the cytoplasm of a mammalian host cell. The VV genome contains 196 open reading frames which are expressed in a highly regulated and temporal fashion in order to...
Resource Type:: Dissertation
Full Text:: more detail, three abundant virion protein constituents 4a, 4b, and 25K were chosen as models for

Proteolytic maturation of Vaccinia virus structural proteins : enzyme and substrate analysis

Creator:: Whitehead, Stephen S.
Resource Type:: Dissertation
Full Text:: . Three potential AG*X cleavage sites have been identified in the P4a precursor protein. Peptide mapping

ScholarsArchive@OSU

Advances in expression of heterologous protein products by Streptococcus gordonii

Characterization of vaccinia virus A12L protein : its proteolysis and functional analyses in virus replication

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Disulphide bond formation is essential for vaccinia virus late protein L1R function and for production of infectious progeny

Fatty acylation of Vaccinia virus proteins : dual myristylation and palmitylation of the A-type inclusion protein

Identification and analysis of vaccinia virus acylproteins

Palmitylation of vaccinia virus proteins : identification of modification sites and biological relevance

Proteolytic maturation of vaccinia virus structural proteins

Proteolytic maturation of Vaccinia virus structural proteins : enzyme and substrate analysis

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