Skin is the largest organ in the body that protects the organism from environmental, chemical and physical traumas of each passing day. The protective skin epidermal permeability barrier (EPB) is formed within the exterior layers of the epidermis, which are regularly sloughed off and repopulated by movement of inner cells....
Cutaneous melanoma remains the deadliest form of skin cancer, with a
diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. Previous studies determined that mice selectively lacking the nuclear hormone...
Mammalian skin is the largest organ of the body and serves as a barrier to protect the body against chemical, mechanical and pathogenic insults as well as water loss. The epidermis is formed from the primitive ectoderm into a multilayered stratified epithelium, consisting of basal, spinous, granular and outermost cornified...
BCL11B, also known as CTIP2, is a transcription factor which plays a critical role in the regulation and development of many tissues and organ systems, including the skin. A 2019 study by Goos et. al. uncovered a novel point mutation in BCL11B gene that converted the Arginine(R)-3 residue to a...
Cutaneous melanoma remains the deadliest form of skin cancer arising from malignant transformation of pigment-producing melanocytes, with a diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. This DNA damage...