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Filtering by: Committee Member Greenwood, Jeffery A Advisor Ishmael, Jane E.

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Creator:

Serrill, Jeffrey D.

Abstract:

Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...

Resource Type:

Dissertation

Full Text:

. Ishmael Natural products from both terrestrial and marine sources represent a significant source of
Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Creator:

Hau, Andrew M.

Abstract:

Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...

Resource Type:

Dissertation

Full Text:

Jang and Jeffrey A. Greenwood. Syntheses and preparation of putative coibamide A and related