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Filtering by: Committee Member Magnusson, Kathy Advisor Ishmael, Jane E.

Natural Products as Pharmacological Tools to probe Mitochondrial and Secretory Function in Cancer Cells

Creator:

Wan, Xuemei

Abstract:

Cancer is the second leading cause of death in the United States. To date, over 60% of current anticancer drugs were inspired by the discovery of chemical structure from nature, commonly known as a natural product. This work represents the biological characterization of several marine natural product compounds and their...

Resource Type:

Dissertation

Full Text:

for drug screening. I owe a special thanks to my committee members Dr. Conroy Sun, Dr. Kathy
Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:

Bajaj, Gaurav

Abstract:

EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...

Resource Type:

Dissertation

Full Text:

, Dr. Kathy Magnusson, and Dr. David Williams for their guidance and encouragement. I would also
Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Creator:

Hau, Andrew M.

Abstract:

Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...

Resource Type:

Dissertation