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Filtering by: Creator Ekstrom, Julia A. Advisor Iversen, Patrick Commencement Year Unknown

Alternative Exon 3 Inclusion in the Vitamin D Receptor (VDR) Modulates Transcriptional Activity for Target Genes in a Ligand-Independent Manner

Creator:

Cameron, Alex N., Annalora, Andrew, and Marcus, Craig

Abstract:

Xenobiotic exposures may induce alternative splicing in the pre-mRNA of nuclear hormone receptor (NHR) genes, yielding unpredictable patterns of gene expression that may promote adverse drug events and promote environmental disease. Informed by observations in the androgen receptor (AR; class I NHR), whereby alternatively-spliced AR transcripts induce ligand-independent hormone signaling...

Resource Type:

Poster

Full Text:

Vitamin D Receptor (VDR) Modulates Transcriptional Activity for Target Genes in a Ligand-Independent