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Filtering by: Advisor Iwaniec, Urszula Date issued sim 2010-05-28

Hypothalamic Leptin Gene Therapy Does Not Prevent Ovariectomy-Induced Bone Loss in Rats

Creator:

Jackson, Melanie A.

Abstract:

Post-menopausal women are at an increased risk for osteoporosis due to increased bone resorption associated with estrogen deficiency. Subcutaneous administration of leptin, a hormone produced primarily by adipocytes, attenuates bone loss in the ovariectomized (ovx) rat, an animal model for post-menopausal bone loss. Leptin has both direct peripheral and indirect...

Resource Type:

Honors College Thesis