Hyperuricemia is the condition of excessive presence of plasma uric acid ≥ 6 mg/dl. Conventional clinical/hospital urate-lowering treatment includes the administration of non-steroid anti-inflammatory drugs or xanthine oxidase inhibitors. Numerous drawbacks can be observed from these conventional treatments. In patients with refractory gout symptoms and tumor lysis syndrome, recombinant uricase...
The Jovanovic lab at Oregon State University (OSU) is developing iCore, a versatile blood processing platform which leverages microfluidic process intensification via increased mass transfer efficiency and decreased device footprint with the goal of creating a portable, wearable device. One application of iCore is for the treatment of hyperferremia resulting...
In order to synthesize polyethylene by the microreactor with a catalyst, this thesis prepares the chemical coating layers for the reactor channel. There are two layers in the channel: the Phillips catalysts and an antimony-doped tin oxide layer on glass substrate. The Phillips catalyst help to synthesize polyethylene in the...
Worldwide production of natural gas has surged in the last few decades leading to an economic windfall for many communities, but sometimes these new sources of natural gas are located in geographically isolated locations. These areas are so remote that it isn’t economically feasible to transport this stranded gas to...
Microscale-based technology has potential applications in the medical field. The development of a new microscale medical device requires experimentation and testing. This can be done by creating a breadboard device that can perform the functionalities the final device should be able to do. This breadboard device can also be used...
The catalyst support effect on NiMoS of bio-hydrogenated diesel production was investigated via density functional theory. The activity, stability and selectivity of catalyst on three widely used catalyst supports (Al2O3, TiO2 and SiO2) were studied and compared.
Catalyst-support interaction and Brønsted acidity strength of different catalyst supports were characterized, which...
The micro-based reactor can be considered as two phases: the main fluid and the gel phase. When the reactants p-chlorophenol enters reactor, diffuses from the main fluid to the gel phase. The diffusion and convention of p-chlorophenol happen in the main fluid. However, there is no convection in the gel...
Dry reforming of methane to syngas using CO2 was performed in a solar-driven milli-scale reactor, which converts solar energy to chemical energy. The process aims to upgrade the energy content of the feed stream using sustainable energy. The effect of mean residence time, temperature and CO2:CH4 ratio on conversion and...
Continuous liquid-liquid two-phase separation is needed in microfluidic devices. Due to the small characteristic lengths of microreactors, phenomena such as mass transport via molecular diffusion occur within seconds. Typically, discrete slugs of an extract are created within microchannels for high specific interfacial area to achieve intensified mass transfer. A challenge...
There are approximately 2.2 million cases of End-stage Renal Disease (ESRD) worldwide and current hemodialysis treatment is costly and ultimately insufficient compared to kidney transplantation. There is a strong need to arrive at a better solution for treating ESRD. Microchannel-based hemodialysis is one proposed option, already shown to have improved...