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Filtering by: Creator Burley, Stephen K. Advisor Karplus, P. Andrew Resource Type Dissertation

Structural investigations to understand the mechanisms of two proteins involved in sulfur chemistry : SsuE and cysteine dioxygenase

Creator:

Driggers, Camden McCullough

Abstract:

Sulfur is one of the six elements required during the early stages of the evolution of life, and enzymes involved in sulfur transfer and oxidation are increasingly being recognized as potential drug targets for antimicrobials as well as for therapies for cancer, neurodegenerative and inflammatory diseases. Bacteria are able to...

Resource Type:

Dissertation

Full Text:

studies of G- protein coupled receptors (2012, R. J. Lefkowitz and B. K. Kobilka) and the ribosome
Modeling protein structure at atomic resolution

Creator:

Berkholz, Donald S.

Abstract:

This thesis includes three studies involving different aspects of modeling protein structure. The first study illustrates the levels of insight available from atomic-resolution protein structures. The second study derives general trends of protein geometry from atomic-resolution structures and shows their implications for modeling. The third study creates a model of...

Resource Type:

Dissertation

Full Text:

. Science 246, 1149-1152. Moffat, K., and Ren, Z. (1997). Synchrotron radiation applications to
Exploring Protein Structure: Seeing the Forest and the Trees

Creator:

Brereton, Andrew E.

Abstract:

Life on Earth intimately depends on the function of countless proteins. For the majority of studied proteins, function absolutely depends on conformation (i.e. 3-dimensional shape in solution). The exact nature of how a protein goes from an unfolded linear polypeptide chain to an organized folded molecule is still not known,...

Resource Type:

Dissertation