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Filtering by: Creator Kleywegt, Gerard J. Remove constraint Creator: Kleywegt, Gerard J. Advisor Karplus, P. Andrew Remove constraint Advisor: Karplus, P. Andrew

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  • Biophysical analyses of peroxiredoxins and a partner reductase

    Creator:
    Hall, Andrea Renée
    Abstract:
    Peroxiredoxins (Prxs) are dominant peroxide-reducing enzymes with two important roles: they protect all organisms from oxidative damage induced by peroxides, and in eukaryotes, they participate in hydrogen peroxide signaling pathways. This dissertation presents studies aimed at the biophysical characterization of select Prxs and a Prx reductase to elucidate their structure-function...
    Resource Type:
    Dissertation
    Full Text:
    and hemoglobin, awarded to J. C. Kendrew, M. Perutz), there have been 16 Nobel Prizes in chemistry

  • Crystallographic studies of Pyrenophora tritici-repentis ToxA

    Creator:
    Sarma, Ganapathy N.
    Abstract:
    Tan spot of wheat is an economically significant disease caused by the fungal pathogen, Pyrenophora tritici-repentis. Certain races of the fungus secrete Ptr ToxA (ToxA), a 13.2 kDa proteinaceous host-selective toxin that is responsible and sufficient to cause disease in susceptible wheat varieties. Disease symptoms develop only when the ToxA...
    Resource Type:
    Dissertation
    Full Text:
    -wheat interaction. Phytopathology 89, 444-449. 16 6. De Wolf, E. D., Effertz, R. J., Au, S. & Franci

  • Modeling protein structure at atomic resolution

    Creator:
    Berkholz, Donald S.
    Abstract:
    This thesis includes three studies involving different aspects of modeling protein structure. The first study illustrates the levels of insight available from atomic-resolution protein structures. The second study derives general trends of protein geometry from atomic-resolution structures and shows their implications for modeling. The third study creates a model of...
    Resource Type:
    Dissertation
    Full Text:
    glutathione reductase near 1 A resolution. J. Mol. Biol. 382, 371-384. Bradley, P., Misura, K.M.S., and

  • Exploring Protein Structure: Seeing the Forest and the Trees

    Creator:
    Brereton, Andrew E.
    Abstract:
    Life on Earth intimately depends on the function of countless proteins. For the majority of studied proteins, function absolutely depends on conformation (i.e. 3-dimensional shape in solution). The exact nature of how a protein goes from an unfolded linear polypeptide chain to an organized folded molecule is still not known,...
    Resource Type:
    Dissertation