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Filtering by: Subject Dispersing agents -- Toxicology Advisor Kerkvliet, Nancy

Investigations of regulatory T cell induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during a graft-versus-host response

Creator:

Marshall, Nikki B.

Abstract:

The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...

Resource Type:

Dissertation

Full Text:

during the Vietnam War as a component of the Agent Orange defoliant. Most recently, TCDD was used in a