Index Catalog // ScholarsArchive@OSU

Creator:: Shepherd, David M.
Abstract:: The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
Resource Type:: Dissertation
Full Text:: comprised the Kerkvliet laboratory. I would like to thank both Linda Steppan and Julie Oughton for all

Creator:: Rohlman, Diana
Abstract:: The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
Resource Type:: Dissertation
Full Text:: Linda B. Steppan Technical support; critical review of experimental design Zhen Yu Technical

Creator:: Funatake, Castle J.
Abstract:: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Resource Type:: Dissertation
Full Text:: ; critical review of data and manuscnpt Linda B. Steppan Technical support; critical review of experimental

Creator:: DeKrey, Gregory K.
Resource Type:: Dissertation
Full Text:: Linda Hintzman, who put up with me in the beginning, thanks for the memories. To Kitty Gardiner, for

Creator:: Prell, Rodney A.
Resource Type:: Dissertation
Full Text:: review of data and manuscript. Steppan, Linda B. Technical support. Vella, Anthony T. Technical support

Creator:: Choi, Jin-Young, 1964
Abstract:: Exposure to TCDD suppresses the generation of immune responses through unknown mechanisms. Interestingly, TCDD enhances inflammatory responses to various stimuli. The goal of the studies presented in this thesis was to examine the role of hyperinflammation in TCDD-induced immunotoxicity. Previously we observed an increase in Mac-1⁺ cells in the spleen...
Resource Type:: Dissertation
Full Text:: . Kerkvliet. Linda Steppan who helped me from the designing countless experiments to technical support

Creator:: Deyo, James A.
Abstract:: Monocrotaline (MCT) is a member of a class of naturally occurring phytotoxins known as pyrrolizidine alkaloids (PAs). Exposure to PAs can result in liver and cardiopulmonary lesions as well as lymphoid organ atrophy. In the present study C57BI/6 (B6) mice received MCT (0-150 mg/kg/day, po) for 14 days. Overt toxicity...
Resource Type:: Dissertation
Full Text:: Julie Oughton, Linda Steppan, Greg Dekrey, and Cathy Neuman for readily available technical help and

Creator:: Dearstyne, Erica A.
Resource Type:: Dissertation
Full Text:: . A special thanks goes to Linda Steppan and Julie Oughton for all their time and patience with me

ScholarsArchive@OSU