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Filtering by: Subject Antigen presenting cells Advisor Kerkvliet, Nancy I.

Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells

Creator:

Ruby, Carl E.

Abstract:

In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of...

Resource Type:

Dissertation

Full Text:

2,3,7,8 Tetrachlorodibenzo-p-Dioxin on Antigen-Presenting Cells and Molecular Signaling Pathways in