Index Catalog // ScholarsArchive@OSU

The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:: Funatake, Castle J.
Abstract:: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Castle J. Funatake for the

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

Creator:: Shepherd, David M.
Abstract:: The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
Resource Type:: Dissertation
Full Text:: gratitude to Dr. Randolph J. Noelle at Dartmouth Medical School. Randy provided me with my first real

The effect of vitamin B-6 supplementation on lymphocyte responsiveness in independently-living elderly persons

Creator:: Talbott, Mary Catherine
Abstract:: The effect of pyridoxine (PN) supplementation on lymphocyte responsiveness was investigated in 15 elderly volunteers (aged 65-81 years) by measuring lymphocyte proliferation to T and B cell mitogens, lymphocyte subpopulations with monoclonal antibodies (T3, T4, T8) and plasma pyridoxal 5'-phosphate (PLP) concentration at pre-supplementation and after 1 and 2 months...
Resource Type:: Masters Thesis
Full Text:: . Nancy Kerkvliet. I would also like to thank Linda Steppan and Julie Brauner for their

The effect of 3,3',4,4',5,5'-hexachlorobiphenyl on production of interleukins 1 and 2 and lymphocyte proliferation in an allogenic response

Creator:: Levy, Sharon
Abstract:: In vivo generation of cytotoxic T cell activity against alloantigen is suppressed by the aromatic hydrocarbon (Ah) receptor binding 3,3',4,4',5,5'- hexachlorobiphenyl isomer (HxCB). Previous studies in this laboratory suggest that HxCB may alter early event(s) in the activation of cytotoxic T lymphocytes (CTL). Production of and response to interleukins 1...
Resource Type:: Masters Thesis
Full Text:: Thanks to Dr. Nancy Kerkvliet, Linda Steppan and Julie Brauner for sharing their knowledge, patience and

T lymphocyte death as a potential mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immune suppression

Creator:: Dearstyne, Erica A.
Resource Type:: Dissertation
Full Text:: . A special thanks goes to Linda Steppan and Julie Oughton for all their time and patience with me

Involvement of inflammation and associated Mac-1⁺Gr-1⁺ cells in the immune suppression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Creator:: Choi, Jin-Young, 1964
Abstract:: Exposure to TCDD suppresses the generation of immune responses through unknown mechanisms. Interestingly, TCDD enhances inflammatory responses to various stimuli. The goal of the studies presented in this thesis was to examine the role of hyperinflammation in TCDD-induced immunotoxicity. Previously we observed an increase in Mac-1⁺ cells in the spleen...
Resource Type:: Dissertation
Full Text:: . Kerkvliet. Linda Steppan who helped me from the designing countless experiments to technical support

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

Creator:: Rohlman, Diana
Abstract:: The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
Resource Type:: Dissertation
Full Text:: Linda B. Steppan Technical support; critical review of experimental design Zhen Yu Technical

Investigation of the mechanism of 3,3',4,4',5,5'-hexachlorobiphenyl-induced suppression of cytotoxic T lymphocyte activity in C57B1/6 mice : endocrine and cytokine dysregulation

Creator:: DeKrey, Gregory K.
Resource Type:: Dissertation
Full Text:: Linda Hintzman, who put up with me in the beginning, thanks for the memories. To Kitty Gardiner, for

Investigation of the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity in C57B1/6 mice : effects on T cell activation

Creator:: Prell, Rodney A.
Resource Type:: Dissertation
Full Text:: review of data and manuscript. Steppan, Linda B. Technical support. Vella, Anthony T. Technical support

Immunotoxicity of the pyrrolizidine alkaloid monocrotaline in C57B1/6 mice

Creator:: Deyo, James A.
Abstract:: Monocrotaline (MCT) is a member of a class of naturally occurring phytotoxins known as pyrrolizidine alkaloids (PAs). Exposure to PAs can result in liver and cardiopulmonary lesions as well as lymphoid organ atrophy. In the present study C57BI/6 (B6) mice received MCT (0-150 mg/kg/day, po) for 14 days. Overt toxicity...
Resource Type:: Dissertation
Full Text:: Julie Oughton, Linda Steppan, Greg Dekrey, and Cathy Neuman for readily available technical help and

ScholarsArchive@OSU

The influence of aryl hydrocarbon receptor activation on T cell fate

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

The effect of vitamin B-6 supplementation on lymphocyte responsiveness in independently-living elderly persons

The effect of 3,3',4,4',5,5'-hexachlorobiphenyl on production of interleukins 1 and 2 and lymphocyte proliferation in an allogenic response

T lymphocyte death as a potential mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immune suppression

Involvement of inflammation and associated Mac-1⁺Gr-1⁺ cells in the immune suppression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

Investigation of the mechanism of 3,3',4,4',5,5'-hexachlorobiphenyl-induced suppression of cytotoxic T lymphocyte activity in C57B1/6 mice : endocrine and cytokine dysregulation

Investigation of the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity in C57B1/6 mice : effects on T cell activation

Immunotoxicity of the pyrrolizidine alkaloid monocrotaline in C57B1/6 mice

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