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Filtering by: Creator Cirpka, Olaf A. Advisor Kerkvliet, Nancy I.

Involvement of inflammation and associated Mac-1⁺Gr-1⁺ cells in the immune suppression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Creator:

Choi, Jin-Young, 1964

Abstract:

Exposure to TCDD suppresses the generation of immune responses through unknown mechanisms. Interestingly, TCDD enhances inflammatory responses to various stimuli. The goal of the studies presented in this thesis was to examine the role of hyperinflammation in TCDD-induced immunotoxicity. Previously we observed an increase in Mac-1⁺ cells in the spleen...

Resource Type:

Dissertation

Full Text:

+ cells represented a systemic inflammatory response and were an immunomodulatory population that
Immunotoxicity of the pyrrolizidine alkaloid monocrotaline in C57B1/6 mice

Creator:

Deyo, James A.

Abstract:

Monocrotaline (MCT) is a member of a class of naturally occurring phytotoxins known as pyrrolizidine alkaloids (PAs). Exposure to PAs can result in liver and cardiopulmonary lesions as well as lymphoid organ atrophy. In the present study C57BI/6 (B6) mice received MCT (0-150 mg/kg/day, po) for 14 days. Overt toxicity...

Resource Type:

Dissertation

Full Text:

in C57B1/6 mice AN ABSTRACT OF THE THESIS OF James A. Deyo for the degree of Doctor of Philosophy
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

Creator:

Shepherd, David M.

Abstract:

The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...

Resource Type:

Dissertation

Full Text:

contributions to the study. Choi, Jin-Young Dearstyne, Erica A. Hedstrom, Olaf R. Kerkvliet, Nancy I