Index Catalog // ScholarsArchive@OSU

T lymphocyte death as a potential mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immune suppression

Creator:: Dearstyne, Erica A.
Resource Type:: Dissertation
Full Text:: approved: Nancy I. Kerkvliet The immune system is a sensitive target for the toxic effects of 2,3,7,8

Immunotoxicity of the pyrrolizidine alkaloid monocrotaline in C57B1/6 mice

Creator:: Deyo, James A.
Abstract:: Monocrotaline (MCT) is a member of a class of naturally occurring phytotoxins known as pyrrolizidine alkaloids (PAs). Exposure to PAs can result in liver and cardiopulmonary lesions as well as lymphoid organ atrophy. In the present study C57BI/6 (B6) mice received MCT (0-150 mg/kg/day, po) for 14 days. Overt toxicity...
Resource Type:: Dissertation
Full Text:: in C57B1/6 mice AN ABSTRACT OF THE THESIS OF James A. Deyo for the degree of Doctor of Philosophy

Investigation of the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity in C57B1/6 mice : effects on T cell activation

Creator:: Prell, Rodney A.
Resource Type:: Dissertation
Full Text:: Activation. Abstract approved: Nancy I. Kerkvliet T cell activation requires a signal delivered through

The role of proinflammatory mediators in 2,3,7,8-tetrachlorodibenzo-p-dioxin induced immunotoxicities

Creator:: Moos, A. B.
Resource Type:: Dissertation
Full Text:: Immunotoxicities. Abstract Approved Nancy I. Kerkvliet Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD

Development and evaluation of the mallard duck as a model to investigate the immunotoxicity of environmental chemicals

Creator:: Fowles, Jefferson R.
Resource Type:: Dissertation
Full Text:: Evaluation of the Mallard Duck as a Model to Investigate the Immunotoxicity of Environmental Chemicals

Quantification of Cytokine Production Following Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Determine Potential Role in Suppression of the Immune Response in a Graft versus Host (GvH) Model

Creator:: Magaña, Laura Cristal
Abstract:: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent immunosuppressant and a prototypic ligand for the aryl hydrocarbon receptor (AhR). In a graft versus host (GvH) response, treatment with TCDD suppresses a cytotoxic T-lymphocyte (CTL) response by Day 10, concurrent with a T-regulatory (Treg) like phenotype in the donor CD4+ T-cells, observed on Day...
Resource Type:: Undergraduate Thesis and Presentation

The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:: Funatake, Castle J.
Abstract:: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Resource Type:: Dissertation
Full Text:: activated antigen-specific T cells. A graft-versus-host (GVH) model, in which T cells from C57B1/6 (B6

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

Creator:: Rohlman, Diana
Abstract:: The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
Resource Type:: Dissertation
Full Text:: approved: _______________________________________________________ Nancy I. Kerkvliet The aryl

Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells

Creator:: Ruby, Carl E.
Abstract:: In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of...
Resource Type:: Dissertation
Full Text:: of adaptive immune responses, and represent a potential target of TCDD toxicity. Thus, the studies

Method development in in vitro immune response

Creator:: Huber, Jacob
Abstract:: The AhR is a ligand-activated transcription factor that mediates the potent immunosuppressive effects of TCDD. AhR-dependent changes in gene expression appear to alter the differentiation of CD4+ T cells to induce a population of CD4+CD25+ T regulatory cells (Tregs) that suppress the immune response. Ascertaining if and how the AhR...
Resource Type:: Undergraduate Thesis and Presentation

ScholarsArchive@OSU

T lymphocyte death as a potential mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immune suppression

Immunotoxicity of the pyrrolizidine alkaloid monocrotaline in C57B1/6 mice

Investigation of the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity in C57B1/6 mice : effects on T cell activation

The role of proinflammatory mediators in 2,3,7,8-tetrachlorodibenzo-p-dioxin induced immunotoxicities

Development and evaluation of the mallard duck as a model to investigate the immunotoxicity of environmental chemicals

Quantification of Cytokine Production Following Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Determine Potential Role in Suppression of the Immune Response in a Graft versus Host (GvH) Model

The influence of aryl hydrocarbon receptor activation on T cell fate

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells

Method development in in vitro immune response

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