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Filtering by: Subject Tetrachlorodibenzodioxin -- Toxicology Remove constraint Subject: Tetrachlorodibenzodioxin -- Toxicology Advisor Kerkvliet, Nancy I. Remove constraint Advisor: Kerkvliet, Nancy I.

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  • The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

    Creator:
    Shepherd, David M.
    Abstract:
    The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
    Resource Type:
    Dissertation
    Full Text:
    in Toxicology presented on July 2S, 1999. Title: The Effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin

  • The influence of aryl hydrocarbon receptor activation on T cell fate

    Creator:
    Funatake, Castle J.
    Abstract:
    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
    Resource Type:
    Dissertation
    Full Text:
    degree of Doctor of Philosophy in Toxicology presented on May 1. 2006. Title: The Influence of Aryl

  • Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

    Creator:
    Rohlman, Diana
    Abstract:
    The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
    Resource Type:
    Dissertation
    Full Text:
    for the degree of Doctor of Philosophy in Toxicology presented on May 15, 2013. Title