Index Catalog // ScholarsArchive@OSU

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

Creator:: Rohlman, Diana
Abstract:: The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
Resource Type:: Dissertation
Full Text:: certain transcription factors and lineage-specific genes for proteins and cytokines. Therefore, gene

Involvement of inflammation and associated Mac-1⁺Gr-1⁺ cells in the immune suppression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Creator:: Choi, Jin-Young, 1964
Abstract:: Exposure to TCDD suppresses the generation of immune responses through unknown mechanisms. Interestingly, TCDD enhances inflammatory responses to various stimuli. The goal of the studies presented in this thesis was to examine the role of hyperinflammation in TCDD-induced immunotoxicity. Previously we observed an increase in Mac-1⁺ cells in the spleen...
Resource Type:: Dissertation
Full Text:: variety of genes (Figure 2-2: reviewed by Wilson and Safc, 1998). Induction of CYP IA I gene expression

The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:: Funatake, Castle J.
Abstract:: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Resource Type:: Dissertation
Full Text:: of Fas on CD4KJ spleen cells ................ 49 2-10 Apoptosis- and survival-related genes are

The role of proinflammatory mediators in 2,3,7,8-tetrachlorodibenzo-p-dioxin induced immunotoxicities

Creator:: Moos, A. B.
Resource Type:: Dissertation
Full Text:: specific genes (Lai, et al., 1996). The activated AhRC acts as a ligand-activated transcription factor

Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells

Creator:: Ruby, Carl E.
Abstract:: In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of...
Resource Type:: Dissertation
Full Text:: of hormone and cytokine genes. The transcription of the hormone ACTH gene has been shown to

Investigation of the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity in C57B1/6 mice : effects on T cell activation

Creator:: Prell, Rodney A.
Resource Type:: Dissertation
Full Text:: gene transcription (figure 1-2). Several genes involved in xenobiotic metabolism, including

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

Creator:: Shepherd, David M.
Abstract:: The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
Resource Type:: Dissertation
Full Text:: cells which can process antigens and express MHC class II gene products (Male, 1986). However

T lymphocyte death as a potential mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immune suppression

Creator:: Dearstyne, Erica A.
Resource Type:: Dissertation
Full Text:: transcription of genes such as cytochrome P450 1A1 (CYP1A1). The alteration of gene transcription of several

The effect of 3,3',4,4',5,5'-hexachlorobiphenyl on production of interleukins 1 and 2 and lymphocyte proliferation in an allogenic response

Creator:: Levy, Sharon
Abstract:: In vivo generation of cytotoxic T cell activity against alloantigen is suppressed by the aromatic hydrocarbon (Ah) receptor binding 3,3',4,4',5,5'- hexachlorobiphenyl isomer (HxCB). Previous studies in this laboratory suggest that HxCB may alter early event(s) in the activation of cytotoxic T lymphocytes (CTL). Production of and response to interleukins 1...
Resource Type:: Masters Thesis
Full Text:: of genes controlling the expression of MFO activities and other gene products (Poland et al., 1979

Development and evaluation of the mallard duck as a model to investigate the immunotoxicity of environmental chemicals

Creator:: Fowles, Jefferson R.
Resource Type:: Dissertation
Full Text:: activates the transcription of a gene locus including genes for the cytochrome P450 1A1 enzyme (Poland and

ScholarsArchive@OSU

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

Involvement of inflammation and associated Mac-1⁺Gr-1⁺ cells in the immune suppression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

The influence of aryl hydrocarbon receptor activation on T cell fate

The role of proinflammatory mediators in 2,3,7,8-tetrachlorodibenzo-p-dioxin induced immunotoxicities

Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells

Investigation of the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity in C57B1/6 mice : effects on T cell activation

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

T lymphocyte death as a potential mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immune suppression

The effect of 3,3',4,4',5,5'-hexachlorobiphenyl on production of interleukins 1 and 2 and lymphocyte proliferation in an allogenic response

Development and evaluation of the mallard duck as a model to investigate the immunotoxicity of environmental chemicals

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