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Filtering by: Creator Feldman%2C Cynthia Rose Remove constraint Creator: Feldman%2C Cynthia Rose Advisor Kioussi, Chrissa Remove constraint Advisor: Kioussi, Chrissa

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  • Role of Pitx2 in regulation of cardiac remodelling

    Creator:
    Bhatt, Shachi
    Abstract:
    Background: Heart morphogenesis involves chamber formation followed by septation. Septation is the remodeling of the heart from a single channel peristaltic pump to a two channel pump with one-way valves. Several transcription factors have been implicated in the development of congenital cardiac defects. The paired-like homeodomain transcription factor Pitx2 has...
    Resource Type:
    Masters Thesis
    Full Text:
    the CNC cell tracer lineage AP2Cre|ROSAEGFP [20] (Fig. 2C, D). Triple labeling immunohistochemistry

  • Roles of homeodomain transcription factors during organogenesis

    Creator:
    Xu, Jun
    Abstract:
    The spatial and temporal patterning of sequence specific transcription factors (SSTFs) contributes to cell type specification and organ formation during embryogenesis. Homeodomain transcription factors are evolutionally conserved among invertebrate and vertebrate animals. They are responsible for body segmentation and organogenesis. Lbx1 and Pitx2 both are homeodomain transcription factors contributing to...
    Resource Type:
    Dissertation
    Full Text:
    , Baek SH, Rose DW, Hamblet NS, Herman T, Ohgi KA, Lin C, Gleiberman A, Wang J, Brault V, Ruiz-Lozano P

  • The role of the homeodomain transcription factor Pitx2 in regulating skeletal muscle precursor migration and higher order muscle assembly

    Creator:
    Campbell, Adam L.
    Abstract:
    Cells of the ventrolateral dermomyotome delaminate and migrate into the limb buds where they give rise to all muscles of the limbs. The migratory cells proliferate and form myoblasts, which withdraw from the cell cycle to become terminally differentiated myocytes. The regulatory mechanisms that control the later steps of this...
    Resource Type:
    Dissertation
    Full Text:
    . 59. Kioussi C, Briata P, Baek SH, Rose DW, Hamblet NS, et al. (2002) Identification of a Wnt/Dvl

  • The function of the homeobox transcription factor Pitx2 during mammalian skeletal muscle development

    Creator:
    Shih, Hung Ping
    Abstract:
    Homeodomain transcription factors control developmental processes. They pattern body formation, specify cell lineages and switch the onset of gene regulatory cascades. Pitx2, a bicoid-related homeodomain transcription factor, is asymmetrically expressed in the left lateral plate mesoderm and mesoderm-derived tissues. Pitx2 null mice are characterized by failure of body wall closure,...
    Resource Type:
    Dissertation
    Full Text:
    and Lbx1 do not contribute to their formation (Fig. 1-2C, D, arrows). Pitx2 is expressed prior the

  • Gene regulatory networks during muscle development

    Creator:
    Eng, Diana G.
    Abstract:
    Congenital myopathies are caused by heritable mutations in particular genes. Genes mutated in congenital muscular dystrophies often encode cytoskeletal proteins, which contribute to the shape and movement of cells. We would like to know how such molecular defects lead to the muscle weakness in patients. It is therefore important to...
    Resource Type:
    Dissertation
    Full Text:
    , 1333-1341. Kioussi, C., Briata, P., Baek, S.H., Rose, D.W., Hamblet, N.S., Herman, T., Ohgi, K.A