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Filtering by: Creator Rose, Kelly Kathleen Remove constraint Creator: Rose, Kelly Kathleen Advisor Kioussi, Chrissa Remove constraint Advisor: Kioussi, Chrissa

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  • Gene networks during cardiogenesis and skeletal myogenesis

    Creator:
    Ma, Hsiao-Yen
    Abstract:
    Organismal development requires a precisely orchestrated transcriptional program to correctly deploy genetic information into the genome. This process requires sophisticated gene regulatory networks at multiple spatial and temporal levels from early embryonic development to adult physiological conditions. Molecular differences that define cell types are set up during the pattern formation...
    Resource Type:
    Dissertation
    Full Text:
    cardiac neural crest (cNC) cells and (4) the epicardium (Kelly, 2005). The 1st lineage appears shortly

  • Role of Pitx2 in regulation of cardiac remodelling

    Creator:
    Bhatt, Shachi
    Abstract:
    Background: Heart morphogenesis involves chamber formation followed by septation. Septation is the remodeling of the heart from a single channel peristaltic pump to a two channel pump with one-way valves. Several transcription factors have been implicated in the development of congenital cardiac defects. The paired-like homeodomain transcription factor Pitx2 has...
    Resource Type:
    Masters Thesis
    Full Text:
    , 39:1890-1900. 2. Kelly RG: Molecular inroads into the anterior heart field. Trends Cardiovasc Med

  • The function of the homeobox transcription factor Pitx2 during mammalian skeletal muscle development

    Creator:
    Shih, Hung Ping
    Abstract:
    Homeodomain transcription factors control developmental processes. They pattern body formation, specify cell lineages and switch the onset of gene regulatory cascades. Pitx2, a bicoid-related homeodomain transcription factor, is asymmetrically expressed in the left lateral plate mesoderm and mesoderm-derived tissues. Pitx2 null mice are characterized by failure of body wall closure,...
    Resource Type:
    Dissertation
    Full Text:
    expression. The absence of Tbx1 results in sporadic branchiomeric myogenesis (Kelly et al., 2004). Both bHLH

  • Homeodomain Transcription Factor Pitx2 is Required for Muscle Maintenance and Energy Homeostasis

    Creator:
    Lattier, Vera C.
    Abstract:
    Skeletal muscle, the largest organ in the body in mass, is composed by 600 specialized muscles in humans with unique biochemical, physiological and metabolic identities. Skeletal muscles control body movement, locomotion, and nutrient balance. Muscle formation requires precisely orchestrated environmental signals and regulatory gene networks in time and space. Gene...
    Resource Type:
    Dissertation

  • Gene Networks of the Skeletal Muscle Cell

    Creator:
    Singh, Arun J.
    Abstract:
    Skeletal muscle is the largest organ in the body by mass, comprising roughly 40% of total bodyweight in adults. It plays diverse and unique roles that include movement, locomotion, and support for posture and internal organs, among others. The structural foundation for all skeletal muscle in adults is formed early...
    Resource Type:
    Dissertation

  • The role of the homeodomain transcription factor Pitx2 in regulating skeletal muscle precursor migration and higher order muscle assembly

    Creator:
    Campbell, Adam L.
    Abstract:
    Cells of the ventrolateral dermomyotome delaminate and migrate into the limb buds where they give rise to all muscles of the limbs. The migratory cells proliferate and form myoblasts, which withdraw from the cell cycle to become terminally differentiated myocytes. The regulatory mechanisms that control the later steps of this...
    Resource Type:
    Dissertation
    Full Text:
    U, Vivarelli E, Kelly R, Papkoff J, et al. (1998) Differential activation of Myf5 and MyoD by

  • Gene regulatory networks during muscle development

    Creator:
    Eng, Diana G.
    Abstract:
    Congenital myopathies are caused by heritable mutations in particular genes. Genes mutated in congenital muscular dystrophies often encode cytoskeletal proteins, which contribute to the shape and movement of cells. We would like to know how such molecular defects lead to the muscle weakness in patients. It is therefore important to...
    Resource Type:
    Dissertation
    Full Text:
    , 1333-1341. Kioussi, C., Briata, P., Baek, S.H., Rose, D.W., Hamblet, N.S., Herman, T., Ohgi, K.A

  • Roles of homeodomain transcription factors during organogenesis

    Creator:
    Xu, Jun
    Abstract:
    The spatial and temporal patterning of sequence specific transcription factors (SSTFs) contributes to cell type specification and organ formation during embryogenesis. Homeodomain transcription factors are evolutionally conserved among invertebrate and vertebrate animals. They are responsible for body segmentation and organogenesis. Lbx1 and Pitx2 both are homeodomain transcription factors contributing to...
    Resource Type:
    Dissertation
    Full Text:
    , Baek SH, Rose DW, Hamblet NS, Herman T, Ohgi KA, Lin C, Gleiberman A, Wang J, Brault V, Ruiz-Lozano P