The entire human population is chronically exposed to various
contaminants, including lead and chlorinated hydrocarbon pesticides.
Studies were undertaken to assess the effects of chronic exposure to
lead on the toxicities of two such pesticides, lindane and dieldrin.
Mice were given lead as the acetate in drinking water, at levels...
Investigations were undertaken to characterize the toxicity in
animals treated with 1, 3-Bis(2-chloroethyl)-1-nitrosourea (BCNU).
Primary experimental interest in this compound had centered around
its antineoplastic activity; however, clinical application of the compound
resulted in the appearance of delayed toxicity symptoms. A
critical evaluation of the toxicity associated with BCNU has...
Rats given morphine-codeine combinations exhibited significantly
increased hotplate reaction times compared with rats given
an analgesic dose of one agent alone. Genera, species, sex, protein
binding and metabolism were studied as possible implicating factors
for the increased reaction times. Both male and female rats exhibited
increased reaction time, and showed...
Preliminary toxicity studies of BCNU in rats revealed that significant
prolongations of pentobarbital hypnosis were associated with
all doses employed. Investigations were undertaken to determine the
underlying mechanism responsible for this observed effect. Studies
on the in vitro metabolism of pentobarbital by hepatic microsomes
of BCNU-treated animals demonstrated that significant...
There has been no toxicologic proof that the long-term, low-level
exposure of man to chlorophenothane (DDT) is linked with an
increased susceptibility to toxicity or disease. Acute pretreatment
of rats with 75-100 mg/kg DDT has been demonstrated to potentiate
CCI₄-induced hepatotoxicity in that species (McLean and McLean,
1966). Since the...
An enhancement of the therapeutic effect and/or a reduction in
the toxicity have been shown by a variety of antineoplastic compounds
when glucose is added to the treatment schedule. A possible explanation
for this involves a selective change in intracellular pH of the
tumor tissue initiating a greater uptake of...
The relationship of intracellular drug levels and resultant drug activity to intracellular pH (pHi) was studied in the experimental tumors. Glucose (5 g/kg) and/or sodium oxamate (0.1 mmol) were administered to Walker 256 ascites cells and Ehrlich ascites cells, in an attempt to alter pHi as measured by the distribution...
The temporal relationships among selected correlates of
hepatocellular damage were investigated in cordotomized, hypothermic
rats intoxicated with carbon tetrachloride (CC1₄). Rats
were spinally transected between C6 and C7 and allowed to become
hypothermic. CC1₄ (1.25 ml/kg ip) was administered as a 1:1 solution
in corn oil. Plasma alanine aminotransferase (ALT)...
The toxicity of chlorobenzene (CB) was investigated in rainbow
trout following acute ip administration (1. 0 ml/kg, 1:1 in corn oil)
and chronic exposure (2. 1 ppm and 2. 9 ppm) via the water in a continuously
flowing system for 15 and 30 days.
In the acute study, overt toxicity...