Index Catalog // ScholarsArchive@OSU

The effects of L-ascorbic acid, thiamine HCl, or L-cysteine on ethanol and acetaldehyde blood levels and disposition

Creator:: Acholonu, Wilfred W.
Abstract:: The effects of L-ascorbic acid, thiamine HC1, or L-cysteine on acetaldehyde blood levels and disposition were investigated in acetaldehyde- treated rats. Rats were treated with ascorbic acid (2 mmoles/kg), thiamine (0.24 mmole/kg), or cysteine (2 mmoles/kg) one hour before the administration of acetaldehyde (6 mmoles/kg). The results show that each...
Resource Type:: Masters Thesis
Full Text:: The effects of L-ascorbic acid, thiamine HCl, or L

Intracellular pH and the uptake of carcinostatic drugs by selected experimental tumors

Creator:: Hult, Richard Lee
Abstract:: The relationship of intracellular drug levels and resultant drug activity to intracellular pH (pHi) was studied in the experimental tumors. Glucose (5 g/kg) and/or sodium oxamate (0.1 mmol) were administered to Walker 256 ascites cells and Ehrlich ascites cells, in an attempt to alter pHi as measured by the distribution...
Resource Type:: Dissertation
Full Text:: : Robert E. Larson The relationship of intracellular drug levels and resultant drug activity to

Acute and chronic toxicity studies with monochlorobenzene in rainbow trout

Creator:: Dalich, George M.
Abstract:: The toxicity of chlorobenzene (CB) was investigated in rainbow trout following acute ip administration (1. 0 ml/kg, 1:1 in corn oil) and chronic exposure (2. 1 ppm and 2. 9 ppm) via the water in a continuously flowing system for 15 and 30 days. In the acute study, overt toxicity...
Resource Type:: Masters Thesis
Full Text:: . Toxicol. 23, 685-689 Gingerich W. H. Weber L. J. and Larson R. E. (1978) Carbon tetrachloride-induced

Biochemical changes associated with BCNU-induced pulmonary toxicity

Creator:: Jarvi, Eric J.
Abstract:: Male Sprague Dawley rats received a single intraperitoneal dose of BCNU in experiments designed to measure biochemical changes associated with the pulmonary toxicity described for this agent. Changes in serum and lung lavage angiotensin converting enzyme (ACE) activity were measured to detect changes in pulmonary endothelial cell integrity. Alpha-1-proteinase inhibitor...
Resource Type:: Dissertation
Full Text:: , 1985 Typed by Jane L. Jarvi for Eric J. Jarvi Acknowledgements I would like to thank Dr. Larson

Hepatotoxicity of monochlorobenzene in rats and rainbow trout

Creator:: Dalich, George M.
Abstract:: The hepatotoxicity of CB was studied in the Sprague-Dawley rat and rainbow trout. In rats, an ip dosage of 9.8 mmol/kg CB (~̲ LD10) produced evidence of liver toxicity over a 72 hr time course. Sulfobromophthalein (BSP) retention maximized 3-16 hr post treatment and normalized after 72 hr whereas plasma...
Resource Type:: Dissertation
Full Text:: ---7 Redacted for Privacy Abstract Approved: Robert E. Larson The hepatotoxicity of CB was studied

Delayed changes in hepatic mixed function oxygenase enzymes in carmustine (BCNU) treated mice

Creator:: Wilson, Vincent Lee
Resource Type:: Dissertation
Full Text:: for PrivacyAbstract approved: Dr. iobert E. Larson Investigations were undertaken to characterize the

The binding of pentobarbital to hemoglobin and its possible involvement in affecting oxygen dissociation

Creator:: Eldredge, Michael Ben
Abstract:: Pentobarbital binding to hemoglobin, evidence of an interaction between pentobarbital and 2,3-DPG in binding to hemoglobin, and the effect of altered oxygen dissociation on the outcome of barbiturate poisoning were studied. Ultrafiltration and equilibrium dialysis techniques were used to determine the binding of pentobarbital to solutions of purified hemoglobin, diluted...
Resource Type:: Masters Thesis
Full Text:: DISSOCIATION Abstract approved: Redacted for Privacy Robert E. Larson Pentobarbital binding to hemoglobin

The effect of carmustine (BCNU) on hepatic UDP-glucuronyltransferase activity in the rat

Creator:: Giese, Neill Alan
Resource Type:: Masters Thesis
Full Text:: ., 35, 1 (1975). 9. I. Lu and R.E. Larson, Tox. Appl. Pharmacol., 22, 299 (1972). 10. G.J. Dutton, in

Impaired organic anion excretion and cholestasis caused by 1,3-bis-(2-chloroethyl)-1-nitrosourea (carmustine or BCNU) in rats

Creator:: Hoyt, Dale G.
Abstract:: Previous investigation showed that 20 mg/kg BCNU caused inhibition of sulfobromophthalein (BSP) excretion and inhibited bile salt independent bile flow (BSIF) in rats by 48 h after treatment (Hoyt, 1984). The present investigation demonstrated that BCNU inhibited the canalicular step in the excretion of BSP. This was indicated by the...
Resource Type:: Dissertation
Full Text:: (carmustine or BCNU) in Rats Abstract approved: Redacted for Privacy 1 Robert E. Larson Previous

A comparison of the effect of pH change upon the uptake of 5-fluorouracil into rat liver and Walker 256 carcinosarcoma slices

Creator:: Hult, Richard Lee
Abstract:: An enhancement of the therapeutic effect and/or a reduction in the toxicity have been shown by a variety of antineoplastic compounds when glucose is added to the treatment schedule. A possible explanation for this involves a selective change in intracellular pH of the tumor tissue initiating a greater uptake of...
Resource Type:: Masters Thesis
Full Text:: Dr. Robert E. Larson An enhancement of the therapeutic effect and/or a reduction in the toxicity

ScholarsArchive@OSU

The effects of L-ascorbic acid, thiamine HCl, or L-cysteine on ethanol and acetaldehyde blood levels and disposition

Intracellular pH and the uptake of carcinostatic drugs by selected experimental tumors

Acute and chronic toxicity studies with monochlorobenzene in rainbow trout

Biochemical changes associated with BCNU-induced pulmonary toxicity

Hepatotoxicity of monochlorobenzene in rats and rainbow trout

Delayed changes in hepatic mixed function oxygenase enzymes in carmustine (BCNU) treated mice

The binding of pentobarbital to hemoglobin and its possible involvement in affecting oxygen dissociation

The effect of carmustine (BCNU) on hepatic UDP-glucuronyltransferase activity in the rat

Impaired organic anion excretion and cholestasis caused by 1,3-bis-(2-chloroethyl)-1-nitrosourea (carmustine or BCNU) in rats

A comparison of the effect of pH change upon the uptake of 5-fluorouracil into rat liver and Walker 256 carcinosarcoma slices

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

Language

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search