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Delayed changes in hepatic mixed function oxygenase enzymes in carmustine (BCNU) treated mice

Creator:: Wilson, Vincent Lee
Resource Type:: Dissertation
Full Text:: . Mervin J. Moldowan, Gregory B. Fink, Donald J. Reed, and Cliff Michel, a note of gratitude for their

A comparison of the effect of pH change upon the uptake of 5-fluorouracil into rat liver and Walker 256 carcinosarcoma slices

Creator:: Hult, Richard Lee
Abstract:: An enhancement of the therapeutic effect and/or a reduction in the toxicity have been shown by a variety of antineoplastic compounds when glucose is added to the treatment schedule. A possible explanation for this involves a selective change in intracellular pH of the tumor tissue initiating a greater uptake of...
Resource Type:: Masters Thesis
Full Text:: appreciated. A. warm thanks is also extended to the other members of my graduate committee, Dr. Donald Reed

Intracellular pH and the uptake of carcinostatic drugs by selected experimental tumors

Creator:: Hult, Richard Lee
Abstract:: The relationship of intracellular drug levels and resultant drug activity to intracellular pH (pHi) was studied in the experimental tumors. Glucose (5 g/kg) and/or sodium oxamate (0.1 mmol) were administered to Walker 256 ascites cells and Ehrlich ascites cells, in an attempt to alter pHi as measured by the distribution...
Resource Type:: Dissertation
Full Text:: of my program committee: Dr. Lavern Weber, Dr. Gregory Fink, Dr. Ronald Winters, Dr. Donald Reed

Biochemical changes associated with BCNU-induced pulmonary toxicity

Creator:: Jarvi, Eric J.
Abstract:: Male Sprague Dawley rats received a single intraperitoneal dose of BCNU in experiments designed to measure biochemical changes associated with the pulmonary toxicity described for this agent. Changes in serum and lung lavage angiotensin converting enzyme (ACE) activity were measured to detect changes in pulmonary endothelial cell integrity. Alpha-1-proteinase inhibitor...
Resource Type:: Dissertation
Full Text:: toxicity An Abstract of the Thesis of Eric J. Jarvi for the degree of Doctor of Philosophy in Pharmacy

Paracellular/transcellular perturbations in hepatobiliary dysfuntion

Creator:: Gilroy, Duncan J.
Resource Type:: Dissertation
Full Text:: hepatobiliary dysfuntion AN ABSTRACT OF THE THESIS OF Duncan J. Gilroy for the degree of Doctor of Philosophy

Impaired organic anion excretion and cholestasis caused by 1,3-bis-(2-chloroethyl)-1-nitrosourea (carmustine or BCNU) in rats

Creator:: Hoyt, Dale G.
Abstract:: Previous investigation showed that 20 mg/kg BCNU caused inhibition of sulfobromophthalein (BSP) excretion and inhibited bile salt independent bile flow (BSIF) in rats by 48 h after treatment (Hoyt, 1984). The present investigation demonstrated that BCNU inhibited the canalicular step in the excretion of BSP. This was indicated by the...
Resource Type:: Dissertation
Full Text:: stimulated in the presence of flavin mononucleotide and not flavin adenine dinucleotide (Potter and Reed

The effect of carmustine (BCNU) on hepatic UDP-glucuronyltransferase activity in the rat

Creator:: Giese, Neill Alan
Resource Type:: Masters Thesis
Full Text:: pharmacology of the nitrosoureas. 25 BIBLIOGRAPHY 1. D.J. Reed and H.E. May, Life Sci., 16, 1263 (1975

Morphine-codeine interactions in rodents

Creator:: Blank, Jerome W.
Abstract:: Rats given morphine-codeine combinations exhibited significantly increased hotplate reaction times compared with rats given an analgesic dose of one agent alone. Genera, species, sex, protein binding and metabolism were studied as possible implicating factors for the increased reaction times. Both male and female rats exhibited increased reaction time, and showed...
Resource Type:: Masters Thesis
Full Text:: ) ,{,1 j /e Title: MORPHINE-CODEINE INTERACTIONS IN RODENTS Redacted for Privacy ) Abstract approved

Characterization of cholestasis induced by 1,3-bis-(2-chloroethyl)-1-nitrosourea in rats

Creator:: Hoyt, Dale G.
Abstract:: BCNU caused severe cholestasis in rats after a single intraperitoneal injection. The cholestasis was characterized by a selective reduction of the bile salt independent bile flow to 11% of control. Decreased food or water consumption by the treated rats apparently did not contribute to cholestasis. Measurements of plasma Na⁺ and...
Resource Type:: Masters Thesis
Full Text:: ) T j I I 1 1 4 5 8 7 8 9 10 11 12 13 14 15 TIME

Hepatic mixed function oxygenase activity in rats during cholestasis following 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) treatment

Creator:: Stolzenbach, James Carlson, 1954-
Abstract:: Rats were given single i.p. injections of BCNU to investigate changes in hepatic cytochrome P-450 content and specific activity in male rats. Microsomal P-450 levels were unchanged from 6 hours to 7 days after BCNU treatment but by day 21 they had decreased 45%. Ethylmorphine N-demethylase activity (nm product x...
Resource Type:: Dissertation
Full Text:: decreases erythrocyte glutathione reductase activity minutes after dosing and Babson and Reed (28) showed

ScholarsArchive@OSU

Delayed changes in hepatic mixed function oxygenase enzymes in carmustine (BCNU) treated mice

A comparison of the effect of pH change upon the uptake of 5-fluorouracil into rat liver and Walker 256 carcinosarcoma slices

Intracellular pH and the uptake of carcinostatic drugs by selected experimental tumors

Biochemical changes associated with BCNU-induced pulmonary toxicity

Paracellular/transcellular perturbations in hepatobiliary dysfuntion

Impaired organic anion excretion and cholestasis caused by 1,3-bis-(2-chloroethyl)-1-nitrosourea (carmustine or BCNU) in rats

The effect of carmustine (BCNU) on hepatic UDP-glucuronyltransferase activity in the rat

Morphine-codeine interactions in rodents

Characterization of cholestasis induced by 1,3-bis-(2-chloroethyl)-1-nitrosourea in rats

Hepatic mixed function oxygenase activity in rats during cholestasis following 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) treatment

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