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Filtering by: Creator Hipkins, Valerie D. Remove constraint Creator: Hipkins, Valerie D. Advisor Leid, Mark Remove constraint Advisor: Leid, Mark Resource Type Dissertation Remove constraint Resource Type: Dissertation

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  • Molecular mechanisms of peroxisome proliferator-activated receptor signaling

    Creator:
    Dowell, Paul T.
    Abstract:
    Peroxisome proliferator-activated receptors (PPARs) are members of a large group of ligand-regulated transcription factors that includes nuclear receptors for steroid and thyroid hormones, retinoids and vitamin D₃. Synthetic fibrates and thiazolidinediones that bind to and activate PPARs are used efficaciously in humans to remedy hypertriglyceridemia and non-insulin dependent diabetes mellitus,...
    Resource Type:
    Dissertation
    Full Text:
    Cellular Biology Director of Molecular n d Cell r Biology Program Dean of Grad fate School I

  • In vitro and in vivo approaches for the functional characterization of the scaffold protein, GRASP

    Creator:
    Venkataraman, Anand
    Abstract:
    Studies using the pluripotent embryonic carcinoma cell line, P19, as a retinoic acid (RA)-responsive model system have been instrumental towards our understanding of the RA-dependent signaling pathways in development and homeostasis. Grp1-associated scaffold protein (GRASP; also known as Tamalin) was first identified by our group, as a gene robustly induced...
    Resource Type:
    Dissertation
    Full Text:
    . Valerie Peterson, for her expert technical and practical advice. I wish to thank all my former/current

  • Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes

    Creator:
    Golonzhka, Olga
    Abstract:
    CTIP2 is a C2H2 zinc finger transcription factor that plays important yet poorly understood roles in mouse development. CTIP2 is known to be highly expressed in the central nervous system, skin and T lymphocytes during embryogenesis. CTIP2-null mice die perinatally of unknown causes and exhibit defects in multiple organ systems...
    Resource Type:
    Dissertation
    Full Text:
    ‐proline‐rich region, S‐serine rich region; P/S – proline and  serine‐rich region, D/E – acidic region.   C