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Filtering by: Subject Ketoconazole -- Mechanism of action Advisor Leid, Mark

In vitro and in vivo approaches for the functional characterization of the scaffold protein, GRASP

Creator:

Venkataraman, Anand

Abstract:

Studies using the pluripotent embryonic carcinoma cell line, P19, as a retinoic acid (RA)-responsive model system have been instrumental towards our understanding of the RA-dependent signaling pathways in development and homeostasis. Grp1-associated scaffold protein (GRASP; also known as Tamalin) was first identified by our group, as a gene robustly induced...

Resource Type:

Dissertation

Full Text:

in vitro albeit by an unknown mechanism. Furthermore, the in vivo role of GRASP is poorly