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Filtering by: Creator Demessie, E. Sahle Remove constraint Creator: Demessie, E. Sahle Advisor Mahmud, Taifo Remove constraint Advisor: Mahmud, Taifo

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  • Exploring Pactamycin Biosynthesis

    Creator:
    Roland, Jessica
    Abstract:
    Pactamycin, produced by the soil bacterium Streptomyces pactum, is a cytotoxic antibiotic that belongs to the aminocyclitol family of natural products. This antibiotic has shown various forms of biological activity, including antibacterial, antifungal, antimalarial, and antitumor activities. Despite its outstanding biological activity, the mode of formation of its pharmacophore (the...
    Resource Type:
    Honors College Thesis
    Full Text:
    into Escherichia coli BL21 pLysS. SDS-PAGE gel electrophoresis showed that the transformed E. coli

  • Exploring the Synthesis of 4-Deoxygadusol

    Creator:
    Jujjuri, Anantha Poojitha
    Abstract:
    Sunscreen products are used worldwide to protect the skin from ultraviolet radiation. However, some of the ingredients used in sunscreen products are fatal to coral reefs especially in areas where tourism is a large part of the economy. In this study, we explored a synthetic route to produce 4-deoxygadusol, which...
    Resource Type:
    Honors College Thesis
    Full Text:
    acids Corresponding e-mail address: jujjuria@oregonstate.edu 4 ©Copyright by Anantha

  • Regulation of Secondary Metabolite Production in Streptomyces

    Creator:
    Abdullah, Alanzi R.
    Abstract:
    Among the myriad of natural products are pseudosugar-containing secondary metabolites, e.g., the C7-pseudosugar-containing oligosaccharide acarbose, the C6- pseudosugar-containing aminoglycoside antibiotics, and the five-membered ring pseudosugar-containing antibiotic pactamycin. The C7-pseudosugars are normally derived from sedoheptulose 7-phosphate catalyzed by a family of enzymes called sedoheptulose 7-phosphate cyclases (SH7PCs). This family of enzymes...
    Resource Type:
    Dissertation
    Full Text:
    the transcripts of the pactamycin biosynthetic genes in S. pactum wild-type (WT), ΔptmE (ΔE) and Δ

  • Studies on the ecological functions of the antidiabetic drugs acarbose

    Creator:
    Tanoeyadi, Samuel
    Abstract:
    Natural products (a.k.a. secondary metabolites) are produced by living organisms that are not essential for their growth, development, or reproduction, but may play a role in their survival or adaptability in nature. Many secondary metabolites isolated from plants and microbes have found use as molecular probes, drug leads, or medicine...
    Resource Type:
    Masters Thesis
    Full Text:
    ) Corresponding authors *E-mails: benjamin.philmus@oregonstate.edu and Taifo.Mahmud@oregonstate.edu Fax: (+1