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Filtering by: Creator Wickramasekara, S. Advisor Maier, Claudia Resource Type Dissertation

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Creator:

Huang, Lin

Abstract:

Oxidative stress is deﬁned as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...

Resource Type:

Dissertation

Full Text:

Abstract approved: ______________________________________________________ Claudia S. Maier
Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Creator:

Yang, Liping

Abstract:

The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....

Resource Type:

Dissertation

Full Text:

: ______________________________________________________________ Dr. Claudia S. Maier