Index Catalog // ScholarsArchive@OSU

Developing a Method For Quantitation of Organic Acid Exometabolites Released By Streptococcus mutans Biofilm Grown Under Oral Cavity-like Conditions

Creator:: Akmal, Ryaan
Abstract:: Tooth decay in the form of dental caries and cavities is estimated to be among the most common health conditions globally, with treatment of these oral diseases resulting in a massive, world-wide economic burden. The cause of this demineralization of teeth is rooted in the action of complex microbial biofilms...
Resource Type:: Honors College Thesis
Full Text:: : _____________________________________________________ Claudia Maier Tooth decay in the form of dental caries and cavities is estimated to

Aging and oxidative damage to mitochondrial membrane proteins

Creator:: Tong, Tony T.
Abstract:: Mitochondria provide energy for biological cells to function, but this process is also a source of oxygen radicals that are capable of damaging nearby proteins. Mitochondrial protein damage can eventually lead to cell death, especially in the case of heart cells, where mitochondria are present in the highest concentrations. As...
Resource Type:: Honors College Thesis
Full Text:: Approved: _____________________________________________________ Dr. Claudia S. Maier

Alternating Between Amperometric Copper Detection and Potentiometric Calcium Detection on a Carbon-based Ion-selective Electrode

Creator:: Park, Suji
Abstract:: The unique capability of carbon-based ion-selective electrode (ISE) to perform highly sensitive anodic stripping voltammetry, while maintaining all the properties of an ISE, is demonstrated in terms of sensitivity, detection limit, response time and selectivity. Square wave anodic stripping voltammetry involves deposition and dissolution steps of metal ions, which means...
Resource Type:: Masters Thesis
Full Text:: : _____________________________________________________________________ Claudia S. Maier The unique capability of carbon-based ion-selective electrode (ISE) to

Mass spectrometry-based identification and characterization of protein and peptide adducts of lipoxidation-derived aldehydes

Creator:: Chavez, Juan D.
Abstract:: Oxidative stress is recognized as an important underlying factor in the pathogenesis of many degenerative diseases as well as normal senescence. The free radicals, reactive oxygen species (ROS) and electrophiles produced during oxidative stress are capable of modifying nucleic acids, lipids and proteins. There are a variety of oxidative modifications...
Resource Type:: Dissertation
Full Text:: :___________________________ Claudia S. Maier Oxidative stress is recognized as an important underlying factor in the

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Creator:: Tzeng, Shin-Cheng
Abstract:: Alcoholic liver disease (ALD) continues to be one of the major public health problems in the United States and worldwide. Complicated by factors including gender, polymorphisms of alcohol-metabolizing enzymes, immunologic factors, exposures to other substances/drugs, hepatic viral infections, nutritional deficiencies, and obesity, ALD is a complex disease that requires a...
Resource Type:: Dissertation
Full Text:: Model Abstract approved: Dr. Claudia S. Maier Alcoholic liver disease (ALD

Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

Creator:: Wu, Jianyong
Abstract:: The adduction of proteins and other biomolecules by electrophilic lipid peroxidation products such as 4-hydroxy-2-nonenal (HNE), 4-oxo-2-nonenal (ONE), malondialdehyde (MDA) or acrolein (ACR) is thought to be an initiating and/or propagating factor in the pathophysiology of several diseases such as atherosclerosis, diabetes, Alzheimer's, Parkinson's and other age-related disorders. The identification...
Resource Type:: Dissertation
Full Text:: major professor, Dr. Claudia S. Maier for providing guidance, support, encouragement, and trust. In

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Creator:: Zandkarimi, Fereshteh
Abstract:: State-of-the-art, high-resolution mass spectrometry techniques for acquisition of metabolomic and lipidomic data coupled with advanced computational methods provide new opportunities for interpreting large and complex datasets and comprehending the underlying biological processes of diseases. Both metabolomics and lipidomics strive to obtain comprehensive analyses of small molecules, i.e., metabolites and lipids,...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Claudia S. Maier State-of-the-art, high-resolution mass spectrometry techniques for

Method validation of quantitative analysis of oxylipins in human plasma via mass spectrometry

Creator:: Bloom, Madeline B.
Abstract:: Oxylipins are a class of bioactive lipid metabolites derived from polyunsaturated fatty acids (PUFAs) via enzymatic and non-enzymatic pathways. In order to elucidate their overall biological effects, the knowledge of the entire oxylipin profile is needed as oxylipins can have similar or opposing effects in regard to inflammatory events. Their...
Resource Type:: Honors College Thesis
Full Text:: Abstract approved: _____________________________________________________ Claudia Maier Oxylipins

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Creator:: Nirudodhi, Sasidhar N.
Abstract:: Proteins are essential to all biological systems. Proteins participate in numerous cellular processes by interacting with other proteins, other metabolites and membranes in a dynamic environment. Studying the structural and conformational properties of proteins in the solution phase is necessary to understand their protein folding and interaction dynamics. This research...
Resource Type:: Dissertation
Full Text:: Conformational Dynamics in Large Protein Complexes Abstract approved: Claudia S. Maier Proteins are essential

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Creator:: Wang, Jing
Abstract:: Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
Resource Type:: Dissertation
Full Text:: : Claudia S. Maier Dysfunction of mitochondria has been linked to aging and the pathogenesis of many

ScholarsArchive@OSU

Developing a Method For Quantitation of Organic Acid Exometabolites Released By Streptococcus mutans Biofilm Grown Under Oral Cavity-like Conditions

Aging and oxidative damage to mitochondrial membrane proteins

Alternating Between Amperometric Copper Detection and Potentiometric Calcium Detection on a Carbon-based Ion-selective Electrode

Mass spectrometry-based identification and characterization of protein and peptide adducts of lipoxidation-derived aldehydes

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Method validation of quantitative analysis of oxylipins in human plasma via mass spectrometry

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

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