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Filtering by: Creator Karas, Michael Remove constraint Creator: Karas, Michael Advisor Maier, Claudia S. Remove constraint Advisor: Maier, Claudia S.

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  • Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

    Creator:
    Wu, Jianyong
    Abstract:
    The adduction of proteins and other biomolecules by electrophilic lipid peroxidation products such as 4-hydroxy-2-nonenal (HNE), 4-oxo-2-nonenal (ONE), malondialdehyde (MDA) or acrolein (ACR) is thought to be an initiating and/or propagating factor in the pathophysiology of several diseases such as atherosclerosis, diabetes, Alzheimer's, Parkinson's and other age-related disorders. The identification...
    Resource Type:
    Dissertation
    Full Text:
    MS/MS analysis were performed to confirm the adduct type and the modification sites. Michael

  • Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

    Creator:
    Wang, Jing
    Abstract:
    Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
    Resource Type:
    Dissertation
    Full Text:
    conducted in our group, i.e., Michael addition by 2-alkenals and disulfide exchange via glutathionylation

  • Aging and oxidative damage to mitochondrial membrane proteins

    Creator:
    Tong, Tony T.
    Abstract:
    Mitochondria provide energy for biological cells to function, but this process is also a source of oxygen radicals that are capable of damaging nearby proteins. Mitochondrial protein damage can eventually lead to cell death, especially in the case of heart cells, where mitochondria are present in the highest concentrations. As...
    Resource Type:
    Honors College Thesis
    Full Text:
    carbon-3 site by Michael-type addition. 1.4. Mass Spectrometry 1.4.1. Introduction to Mass Spectrometry