Index Catalog // ScholarsArchive@OSU

Creator:: Chavez, Juan D.
Abstract:: Oxidative stress is recognized as an important underlying factor in the pathogenesis of many degenerative diseases as well as normal senescence. The free radicals, reactive oxygen species (ROS) and electrophiles produced during oxidative stress are capable of modifying nucleic acids, lipids and proteins. There are a variety of oxidative modifications...
Resource Type:: Dissertation
Full Text:: . Phil Watson, Dr. Manish Gupta, Dr. Larry Daley, and Dr. Fred Stevens. I would also like to thank

Creator:: Wang, Jing
Abstract:: Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
Resource Type:: Dissertation
Full Text:: , Fred Stevens, Ron Wrolstad and Gregory Rorrer. I would also like to express my appreciation to all

Creator:: Tzeng, Shin-Cheng
Abstract:: Alcoholic liver disease (ALD) continues to be one of the major public health problems in the United States and worldwide. Complicated by factors including gender, polymorphisms of alcohol-metabolizing enzymes, immunologic factors, exposures to other substances/drugs, hepatic viral infections, nutritional deficiencies, and obesity, ALD is a complex disease that requires a...
Resource Type:: Dissertation
Full Text:: : Professors Tory Hagen, Fred Stevens, Victor Hsu and Neal Sleszynski. I would also like to express my

Creator:: Tong, Tony T.
Abstract:: Mitochondria provide energy for biological cells to function, but this process is also a source of oxygen radicals that are capable of damaging nearby proteins. Mitochondrial protein damage can eventually lead to cell death, especially in the case of heart cells, where mitochondria are present in the highest concentrations. As...
Resource Type:: Honors College Thesis
Full Text:: ACKNOWLEDGEMENT First of all, I would like to thank my mentors, Dr. Claudia Maier and Dr. Fred Stevens for the

Creator:: Zandkarimi, Fereshteh
Abstract:: State-of-the-art, high-resolution mass spectrometry techniques for acquisition of metabolomic and lipidomic data coupled with advanced computational methods provide new opportunities for interpreting large and complex datasets and comprehending the underlying biological processes of diseases. Both metabolomics and lipidomics strive to obtain comprehensive analyses of small molecules, i.e., metabolites and lipids,...
Resource Type:: Dissertation
Full Text:: that I needed at the time. I would like to thank Fred Stevens for his constructive comments in the

Creator:: Khorani, Mona
Abstract:: Metabolomics has recently gained momentum in biomolecule research and complements the genomics and proteomics research space. Metabolomics strives to detect, identify, and quantify all metabolites present in biological samples. In particular, biomolecular analysis using ultra-performance liquid chromatography combined with mass spectrometry (UPLC-MS) has become increasingly important for metabolomic analyses. Similarly,...
Resource Type:: Dissertation
Full Text:: support throughout my journey. I would like to thank Prof. Fred Stevens, Dr. Jaewoo Choi, and the Linus

ScholarsArchive@OSU