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Filtering by: Alternative title ssim Circular of information no. 254 Remove constraint Alternative title ssim: Circular of information no. 254 Advisor Mathews, Christopher K. Remove constraint Advisor: Mathews, Christopher K. Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.)

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Bacteriophage T4-coded dihydrofolate reductase : cloning and structural analysis of its gene and organization of flanking regions

Creator:

Purohit, Sarla

Abstract:

The dihydrofolate reductase gene of bacteriophate T4 has been investigated at the structural level to elucide the unusual regulation of expression of this gene and possible evolutionary relationships between the ohage and drug resistance factors-encoded dihydrofolate reductases (DHFR). A 1.1-kilobase-pair restriction fragment of the T4 multiple mutant dec8 containing frd,...

Resource Type:

Dissertation

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least five sequences which show homology to the consensus sequence of E. coli promoters; however, no
Oligoribonucleotides directed at ribosomal protein binding sites as inhibitors of ribosomal small subunit assembly and as possible antibiotics

Creator:

Thompson, Cynthia Sue

Abstract:

The effects of oligoribonucleotides of identical or similar sequences to a ribosomal protein binding site, specifically S8, on prokaryotic 30S ribosomal assembly were investigated in Escherichia coli. The oligoribonucleotides were expected to bind to the target protein S8 and block its incorporation into the 30S subunit, resulting in a nonfunctional...

Resource Type:

Dissertation

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experiments were performed in the presence and absence of the inducer isopropylthiogalactoside (lPTG). No
Deoxyribonucleotides as determinants of DNA replication fidelity in bacteriophage T4

Creator:

Sargent, Roy Geoffrey

Abstract:

Imbalanced deoxyribonucleoside triphosphate (dNTP) pools are mutagenic for DNA synthesis in both intact cells and cell-free replication systems. Almost certainly, such mutagenesis involves competition between correctly and incorrectly base-paired precursors at replication sites. However, there are certain differences between the intact cell and cell-free systems that do not always allow...

Resource Type:

Dissertation

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Deoxyribonucleotides as determinants of DNA replication
Vaccinia virus ribonucleotide reductase : gene sequencing, intracellular localization, and interaction with a DNA-binding protein

Creator:

Davis, Ralph Eugene, 1957-

Abstract:

Vaccinia virus infected monkey kidney cells had been previously shown to have an increased ribonucleoside diphosphate reductase (RR) activity. DNA from mutant virus resistant to hydroxyurea were digested with restriction endonucleases and were shown to have substoichiometric amounts of the Hind III F fragment. Additional information from Southern blotting experiments...

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Dissertation

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there has been no reported splicing of vaccinia transcripts. The early RNA is extruded from the viral
Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

Creator:

Ji, Jiuping

Abstract:

A crucial factor in determining the accuracy of DNA replication is maintenance of a balanced supply of deoxyribonucleoside triphosphates (dNTPs) at replication forks. Perturbation of dNTP biosynthesis can induce dNTP pool imbalance with deleterious genetic consequences, including increased mutagenesis, recombination, chromosomal abnormalities and cell death. Using the T4 bacteriophage system,...

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Dissertation

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molecule, the genetic map is circular due to circular permutation of base sequences in the genome (Mathews
Modulation of deoxyribonucleoside triphosphate levels, DNA synthesis rates and fidelity in mammalian cells

Creator:

Martomo, Stella A.

Abstract:

Deoxyribonucleoside triphosphate (dNTP) concentrations measured in cells are not symmetric. dGTP almost always represents only 5-10% of the total dNTP pools in cells. In an in vitro replication system involving semiconservative replication from an SV 40 origin, the mutation frequency of an M13 phagemid replicated by human cell extracts in...

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Dissertation

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vitro for the maturation of daughter DNA molecules into closed circular form I DNA (Waga and Stillman
Regulation of ribonucleotide reductase analyzed by simultaneous measurement of the four enzyme activities

Creator:

Hendricks, Stephen P.

Abstract:

The first committed step in DNA biosynthesis occurs by direct reduction of ribonucleotides. This reduction is catalyzed by ribonucleotide reductase (RNR), an enzyme which uses a unique radical mechanism to facilitate the transformation. All four DNA precursors are synthesized by a single enzyme. Therefore, an intricate pattern of regulation has...

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Dissertation

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Regulation of ribonucleotide reductase analyzed by
Nucleoside diphosphokinase of Escherichia coli and its interactions with bacteriophage T4 proteins of DNA synthesis

Creator:

Ray, Nancy Bisset

Resource Type:

Dissertation

Full Text:

ndk gene. However, there was no mutant available and the background activity of NDPK was fairly high
DNA precu[r]sor compartmentation in mammalian cells : metabolic and anti-metabolic studies of nuclear and mitochondrial DNA synthesis

Creator:

Bestwick, Richard Keith

Abstract:

This dissertation describes an investigation of DNA precursor supply for mitochondrial and nuclear DNA synthesis in HeLa cells and Mouse L-cells. HeLa cells were used for the quantitation of cellular and mitochondrial deoxyribonucleoside triphosphate (dNTP) and ribonucleoside triphosphate (rNTP) pools and of changes in pools in response to treatment with...

Resource Type:

Dissertation

Full Text:

economy of genetic information. There are no introns in any genes, very few if any non-coding bases
Organization of the T4 dNTP synthetase complex at DNA replication sites

Creator:

Kim, JuHyun

Abstract:

With respect to a multienzyme complex of deoxyribonucleoside triphosphate (dNTP) synthesis somehow juxtaposed with DNA replication sites, our laboratory has demonstrated the existence of a multienzyme complex in T4-infected E. coli, named the T4 dNTP synthetase complex, but the idea of direct linkage of dNTP synthesis to DNA replication and...

Resource Type:

Dissertation

Full Text:

cell cycle, Figure 1.1 summarizes information about the pathway of dNTP synthesis in T4-infected

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Academic Affiliation

Biochemistry and Biophysics16

Advisor

Mathews, Christopher K.[remove]20

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 1983 to 2007

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Committee Member

Anderson, Sonia2
Hsu, Victor L.2
Mosbaugh, Dale2
Pearson, George D.2
Anderson, Sonia R.1
more Committee Members »

Creator

Bernard, Mark Aguirre1
Bestwick, Richard Keith1
Davis, Ralph Eugene, 1957 1
Hanson, Eric Scott1
Hendricks, Stephen P.1
more Creators »

Date

Date range begin – Date range end

Current results range from 1982 to 2006

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Decade

2000-20096
1990-19999
1980-19895

Degree Field

Biochemistry and Biophysics16
Genetics2
Molecular and Cellular Biology2

Degree Level

Doctoral20

Degree Name

Doctor of Philosophy (Ph.D.)[remove]20

File Format

application/pdf1

Language

English [eng]20

License

All rights reserved3

Non-Academic Affiliation

Oregon State University. Graduate School20

Peer Reviewed

No20

Resource Type

Dissertation20

Rights Statement

Copyright Not Evaluated17
In Copyright3

Subject

Bacteriophage T48
DNA -- Synthesis8
DNA replication4
DNA2
DNA damage2
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