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Filtering by: Creator Prasad, Prem Advisor Mathews, Christopher K. Degree Name Doctor of Philosophy (Ph.D.)

Modulation of deoxyribonucleoside triphosphate levels, DNA synthesis rates and fidelity in mammalian cells

Creator:

Martomo, Stella A.

Abstract:

Deoxyribonucleoside triphosphate (dNTP) concentrations measured in cells are not symmetric. dGTP almost always represents only 5-10% of the total dNTP pools in cells. In an in vitro replication system involving semiconservative replication from an SV 40 origin, the mutation frequency of an M13 phagemid replicated by human cell extracts in...

Resource Type:

Dissertation