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Vaccinia virus ribonucleotide reductase : gene sequencing, intracellular localization, and interaction with a DNA-binding protein

Creator:: Davis, Ralph Eugene, 1957-
Abstract:: Vaccinia virus infected monkey kidney cells had been previously shown to have an increased ribonucleoside diphosphate reductase (RR) activity. DNA from mutant virus resistant to hydroxyurea were digested with restriction endonucleases and were shown to have substoichiometric amounts of the Hind III F fragment. Additional information from Southern blotting experiments...
Resource Type:: Dissertation

The effects of protein associations on pyrimidine deoxyribonucleotide biosynthesis

Creator:: McGaughey, Kathleen M.
Abstract:: The faithful replication of DNA depends on the appropriate balance of DNA precursors. From studies conducted in bacteriophage T4, models for deoxyribonucleotide biosynthesis producing pools appropriate for DNA replication have made it possible to understand more complex systems. A portion of that body of evidence supports the concept that deoxyribonucleotide...
Resource Type:: Dissertation
Full Text:: .- DNA NA Figure Ii. / \ 4Z-4 r tL #.,_w. '.tA ,.J / . ,.,.,.L_.. _,_Ic__fl II NA NA NANA. 8 S-NA

Regulation of mouse ribonucleotide reductase by allosteric effector-substrate interplay and hypoxia

Creator:: Chimploy, Korakod
Abstract:: In order to maintain genetic stability in eukaryotes, tight regulation of the relative sizes of deoxyribonucleoside triphosphate (dNTP) levels inside the cell is essential for optimal fidelity of DNA replication. Ribonucleotide reductase (RNR) is the enzyme responsible for proportional production of DNA precursors. Studies on regulation of this enzyme, the...
Resource Type:: Dissertation
Full Text:: committee members, Drs. Walt Ream, Lyle R. Brown, William Baird, and Linda Blythe for their support and

Protein-protein interactions in the bacteriophage T4-coded dCTPase-dUTPase

Creator:: Ungermann, Christian
Resource Type:: Masters Thesis
Full Text:: beyond our research horizon. I would also like to thank Linda Wheeler, Eric Hanson, and all of my

Protein-protein interactions in the bacteriophage T4 dNTP synthetase complex

Creator:: Shen, Rongkun
Abstract:: The enzymes of dNTP synthesis in T4 infection associate to form a multienzyme complex, the T4 dNTP synthetase complex, facilitating the flow of metabolites en route to dNTPs, and their subsequent flow into DNA. Study of protein-protein interactions helps one to understand how the enzymes in the complex are organized...
Resource Type:: Dissertation
Full Text:: , especially Linda J. Wheeler (Benson) and Dr. Indira Rajagopal for their kind technical advice and support

Precursors for mitochondrial DNA replication : metabolic sources and relations to mutagenesis and human diseases

Creator:: Song, Shiwei
Abstract:: It is well known that the mitochondrial genome has a much higher spontaneous mutation rate than the nuclear genome. mtDNA mutations have been identified in association with many diseases and aging. mtDNA replication continues throughout the cell cycle, even in post-mitotic cells. Therefore, a constant supply of nucleotides is required...
Resource Type:: Dissertation
Full Text:: also like to thank Dr. Tory M. Hagen, Dr. Indira Rajagopal and Ms.Linda J. Wheeler for their advice

Organization of the T4 dNTP synthetase complex at DNA replication sites

Creator:: Kim, JuHyun
Abstract:: With respect to a multienzyme complex of deoxyribonucleoside triphosphate (dNTP) synthesis somehow juxtaposed with DNA replication sites, our laboratory has demonstrated the existence of a multienzyme complex in T4-infected E. coli, named the T4 dNTP synthetase complex, but the idea of direct linkage of dNTP synthesis to DNA replication and...
Resource Type:: Dissertation
Full Text:: to thank my committee members, Drs. Barbara J. Taylor, Walter Ream, Michael M. Schimerlik, and

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Creator:: Wang, Yeong
Abstract:: Bacteriophage T4 gene 42 encodes dCMP hydroxymethylase, an enzyme unique to the deoxyribonucleotide metabolism of T-even bacteriophages. To study biochemical and biophysical properties of the enzyme, as well as the interaction of dCMP hydroxymethylase with other DNA precursor biosynthetic enzymes in vitro, availability of large amounts of the enzyme is...
Resource Type:: Dissertation
Full Text:: Lasser, and Linda Wheeler for their help in my research efforts. Finally, my deepest appreciation is

Nucleoside diphosphokinase of Escherichia coli and its interactions with bacteriophage T4 proteins of DNA synthesis

Creator:: Ray, Nancy Bisset
Resource Type:: Dissertation
Full Text:: thank Gerry Lasser and Linda Wheeler for allowing me to benefit from their expertise. I greatly

Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

Creator:: Ji, Jiuping
Abstract:: A crucial factor in determining the accuracy of DNA replication is maintenance of a balanced supply of deoxyribonucleoside triphosphates (dNTPs) at replication forks. Perturbation of dNTP biosynthesis can induce dNTP pool imbalance with deleterious genetic consequences, including increased mutagenesis, recombination, chromosomal abnormalities and cell death. Using the T4 bacteriophage system,...
Resource Type:: Dissertation
Full Text:: and the members in his laboratory: Dr. Mary Slabaugh, Dr. Nancy Roseman, Linda Wheeler, Ralph Davis

ScholarsArchive@OSU

Vaccinia virus ribonucleotide reductase : gene sequencing, intracellular localization, and interaction with a DNA-binding protein

The effects of protein associations on pyrimidine deoxyribonucleotide biosynthesis

Regulation of mouse ribonucleotide reductase by allosteric effector-substrate interplay and hypoxia

Protein-protein interactions in the bacteriophage T4-coded dCTPase-dUTPase

Protein-protein interactions in the bacteriophage T4 dNTP synthetase complex

Precursors for mitochondrial DNA replication : metabolic sources and relations to mutagenesis and human diseases

Organization of the T4 dNTP synthetase complex at DNA replication sites

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Nucleoside diphosphokinase of Escherichia coli and its interactions with bacteriophage T4 proteins of DNA synthesis

Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

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