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Filtering by: Creator L’Heureux, K. Remove constraint Creator: L’Heureux, K. Advisor Mathews, Christopher K. Remove constraint Advisor: Mathews, Christopher K.

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  • Studies on DNA precursor metabolism in vaccinia virus-infected mamalian cells

    Creator:
    Spiro, Craig
    Abstract:
    Vaccinia virus-infected animal cells have been used to study the interactions between the replication of deoxyribonucleic acid (DNA) and the biosynthesis of its nucleotide precursors. Some antimetabolites that inhibit DNA replication have as their targets enzymes of nucleotide biosynthesis. Furthermore, the disruption of nucleotide metabolism can alter the fidelity of...
    Resource Type:
    Dissertation
    Full Text:
    Metabolism in Vaccinia Virus-Infected Mammalian Cells. Abstract Redacted for Privacyapproved: Christopher K

  • Deoxyribonucleotides as determinants of DNA replication fidelity in bacteriophage T4

    Creator:
    Sargent, Roy Geoffrey
    Abstract:
    Imbalanced deoxyribonucleoside triphosphate (dNTP) pools are mutagenic for DNA synthesis in both intact cells and cell-free replication systems. Almost certainly, such mutagenesis involves competition between correctly and incorrectly base-paired precursors at replication sites. However, there are certain differences between the intact cell and cell-free systems that do not always allow...
    Resource Type:
    Dissertation
    Full Text:
    privacy Christopher K. Mathews Imbalanced deoxyribonucleoside triphosphate (dNTP) pools are mutagenic