Index Catalog // ScholarsArchive@OSU

Enzyme associations in deoxyribonucleotide biosynthesis : anti-idiotypic antibodies as probes for direct protein-protein interactions

Creator:: Young, James Patrick
Abstract:: The ability to faithfully replicate DNA is dependent upon the maintenance and regulation of its precursors, the deoxyribonucleoside triphosphates. Enzymes encoded by the bacteriophage T4 have been widely used as models of biochemical processes. A body of evidence supports the concept that the bacteriophage T4 enzymes involved in deoxyribonucleotide biosynthesis...
Resource Type:: Dissertation

Bacteriophage T4 ribonucleotide reductase : genes and proteins

Creator:: Hanson, Eric Scott
Resource Type:: Dissertation
Full Text:: aspects of the molecular biology of T4 has recently been published (Karam, 1994). Following adsorption of

Alternatives to the DNA precursor-synthesizing enzyme complex hypothesis

Creator:: Weitz, Stephen L.
Abstract:: Investigators have been studying an aggregate containing enzymes of deoxyribonucleoside triphosphate biosynthesis in T4-phage infected bacteria. They suggest that it behaves as an organized complex, efficiently channeling DNA precursors to the replication apparatus. Previous work has suggested that about 10 enzyme activities remain associated through several fractionation steps. This multi-enzyme...
Resource Type:: Dissertation

Protein-protein interactions in the bacteriophage T4-coded dCTPase-dUTPase

Creator:: Ungermann, Christian
Resource Type:: Masters Thesis

Organization of the T4 dNTP synthetase complex at DNA replication sites

Creator:: Kim, JuHyun
Abstract:: With respect to a multienzyme complex of deoxyribonucleoside triphosphate (dNTP) synthesis somehow juxtaposed with DNA replication sites, our laboratory has demonstrated the existence of a multienzyme complex in T4-infected E. coli, named the T4 dNTP synthetase complex, but the idea of direct linkage of dNTP synthesis to DNA replication and...
Resource Type:: Dissertation

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Creator:: Wang, Yeong
Abstract:: Bacteriophage T4 gene 42 encodes dCMP hydroxymethylase, an enzyme unique to the deoxyribonucleotide metabolism of T-even bacteriophages. To study biochemical and biophysical properties of the enzyme, as well as the interaction of dCMP hydroxymethylase with other DNA precursor biosynthetic enzymes in vitro, availability of large amounts of the enzyme is...
Resource Type:: Dissertation

Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

Creator:: Ji, Jiuping
Abstract:: A crucial factor in determining the accuracy of DNA replication is maintenance of a balanced supply of deoxyribonucleoside triphosphates (dNTPs) at replication forks. Perturbation of dNTP biosynthesis can induce dNTP pool imbalance with deleterious genetic consequences, including increased mutagenesis, recombination, chromosomal abnormalities and cell death. Using the T4 bacteriophage system,...
Resource Type:: Dissertation

Nucleoside diphosphokinase of Escherichia coli and its interactions with bacteriophage T4 proteins of DNA synthesis

Creator:: Ray, Nancy Bisset
Resource Type:: Dissertation

The effects of protein associations on pyrimidine deoxyribonucleotide biosynthesis

Creator:: McGaughey, Kathleen M.
Abstract:: The faithful replication of DNA depends on the appropriate balance of DNA precursors. From studies conducted in bacteriophage T4, models for deoxyribonucleotide biosynthesis producing pools appropriate for DNA replication have made it possible to understand more complex systems. A portion of that body of evidence supports the concept that deoxyribonucleotide...
Resource Type:: Dissertation

Host kinases involved in DNA precursor biosynthesis during bacteriophage T4 infection

Creator:: Bernard, Mark Aguirre
Abstract:: Although the Escherichia coli host has almost all of the enzymes necessary to synthesize nucleotides needed for bacteriophage T4 DNA replication, phage genes expressed early in infection encode enzymes for de novo DNA precursor biosynthesis and salvage from degraded host DNA. Eight early enzymes and two host enzymes comprise the...
Resource Type:: Dissertation

ScholarsArchive@OSU

Enzyme associations in deoxyribonucleotide biosynthesis : anti-idiotypic antibodies as probes for direct protein-protein interactions

Bacteriophage T4 ribonucleotide reductase : genes and proteins

Alternatives to the DNA precursor-synthesizing enzyme complex hypothesis

Protein-protein interactions in the bacteriophage T4-coded dCTPase-dUTPase

Organization of the T4 dNTP synthetase complex at DNA replication sites

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

Nucleoside diphosphokinase of Escherichia coli and its interactions with bacteriophage T4 proteins of DNA synthesis

The effects of protein associations on pyrimidine deoxyribonucleotide biosynthesis

Host kinases involved in DNA precursor biosynthesis during bacteriophage T4 infection

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