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Filtering by: Creator Loughborough, W. Karl Remove constraint Creator: Loughborough, W. Karl Advisor Mcguire, Joseph Remove constraint Advisor: Mcguire, Joseph Creator Lee, Hyo Jin Remove constraint Creator: Lee, Hyo Jin

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  • Molecular origins of surfactant-mediated stabilization of protein

    Creator:
    Lee, Hyo Jin
    Abstract:
    Nonionic surfactants are commonly used to stabilize proteins during upstream and downstream processing and drug formulation. Surfactants stabilize the proteins through two major mechanisms: (i) their preferential location at nearby interfaces, in this way precluding protein adsorption; and/or (ii) their association with protein into "complexes" that prevent proteins from interacting...
    Resource Type:
    Dissertation
    Full Text:
    ,b Arnold McAuley,b Karl F. Schilkea and Joseph McGuirea,* aSchool of Chemical, Biological and