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Filtering by: Creator Loughborough, W. Karl Remove constraint Creator: Loughborough, W. Karl Advisor Mcguire, Joseph Remove constraint Advisor: Mcguire, Joseph Degree Level Bachelor's Remove constraint Degree Level: Bachelor's

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  • Quantification of fibrinogen adsorption to nisin-loaded polyethylene oxide layers

    Creator:
    Auxier, Julie A.
    Abstract:
    Antimicrobial coatings used to reduce the risk of infection caused by tissue-contacting medical devices must address specific biocompatibility requirements including prevention of thrombosis and rise of bacterial resistance. An antimicrobial-loaded poly(ethylene-oxide) (PEO) coating has been tentatively shown to be non-fouling with sustained antimicrobial activity. However, the presence of the antimicrobial,...
    Resource Type:
    Honors College Thesis
    Full Text:
    also in my overall professional development. I also extend my gratification to Dr. Karl Schilke for

  • Characterization and application of PEO-containing triblock copolymer surfactants

    Creator:
    Snider, Joshua L.
    Abstract:
    The action of pendant, polyethylene oxide (PEO) brush layers as nonfouling coatings for biomedical materials is well understood. However progress toward clinical application of stable, high density PEO coatings has historically been impeded by the lack of cost effective, noninvasive methods for their preparation. Triblock polymers featuring a hydrophobic, polypropylene...
    Resource Type:
    Honors College Thesis
    Full Text:
    , Dr. Joseph McGuire, Dr. Karl Schilke, and Dr. Phil Harding for all of their valuable guidance

  • Functionalization of Surfaces with Nisin in a Polyethylene Oxide Brush Layer

    Creator:
    Ryder, Matthew P.
    Abstract:
    Infections in hospitals account for over 100,000 deaths per year. These infections occur at the hospital from complications following bacterial adhesion to intravenous catheters, coronary stents and other implanted devices. Another common problem is protein adsorption to the surface of the device and subsequent blood clotting. Methods for combating these...
    Resource Type:
    Honors College Thesis
    Full Text:
    .            Matthew P Ryder, Author      Acknowledgements    I would like to thank Karl Schilke and Jeff Tai for

  • Molecular Origins of Recombinant Factor VIII (rFVIII)

    Creator:
    Tadehara, Katherine M.
    Abstract:
    The capability of Pluronic® F68 to stabilize human recombinant Factor VIII in solution was assessed using zeta potential measurements. Hemophilia A is a genetic disorder in which the body is missing Factor VIII (FVIII) from the blood coagulation cascade. The pharmaceutical industry developed recombinant Factor VIII (rFVIII), the largest cloned...
    Resource Type:
    Honors College Thesis
    Full Text:
    we needed it especially when we started second guessing our math. Thank you, Dr. Karl “Rat” Schilke